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학술대회자료
저자정보
O, Baatartsogt. (School of Applied Life Science, Hankyong National University) So, Hyun-Kyung (School of Applied Life Science, Hankyong National University) Cho, In-Hee (School of Applied Life Science, Hankyong National University) Lee, Jeong-Soo (School of Applied Life Science, Hankyong National University) Lim, Hee-Kyung (School of Applied Life Science, Hankyong National University) Lee, Jong-Ha (Medical Center of Kyung Hee University) Kim, Eun-Kuk (Medical Center of Kyung Hee University) Choi, Kung-Duk (School of Applied Life Science, Hankyong National University)
저널정보
한국축산식품학회 한국축산식품학회 학술발표초록집 한국축산식품학회 2006년도 정기총회 및 제37차 춘계 국제학술발표대회
발행연도
2006.1
수록면
122 - 127 (6page)

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The innermost structures of synovium consist of one to three layers of cells generally identified as synovial lining cells(SLC). The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial(FLS) cells derived from the synovia of rheumatoid arthritis. Post-traumatic arthritis(PTA) is one of the most common causes of secondary osteoarthritis, and usually affects younger people. The proteins were separated by two-dimensional polyacrylamide gel electrophoresis and RNA expression investigated by RT-PCR Proteome analyses led to the identification of more than 1,500 protein spots and of 11 differently expressed protein spots among them. Six proteins were down-regulated, and five proteins were up-regulated in ACL-transected synovial tissue. Among these, spots 3 and 8 were identified as cofilin-1 and smooth muscle protein $22-\alpha$, respectively, Therefore, the proteome analysis of synovial tissue is a useful approach to investigate a joint after an injury and can be used to understand the pathogenesis of PTA.

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