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The pKa' of tranylcypromine was determined by potentiometric titration and ultraviolet spectrophotometric method and found to be 8.08 and 8.15, respectively. The Papp of tranylcypromine between n-heptane and aqueous buffer solution was measured to be 0.90 at pH 7.48 and 4.50 for Pm. The pKa' of tranylcypromine obtained by means of the partition method was 8.13.
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