지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 178 - 182 (5page)
이용수
초록· 키워드
오류제보하기
Nitric oxide (NO) produced from endothelial cells plays a critical role in vascular physiology. The regulation of endothelial NO synthase (eNOS) involves various mechanisms including multiple Ser/Thr phosphorylations. Recently, eNOS-Ser617 was newly recognized to be phosphorylated in response to humoral factors including vascular endothelial growth factor. However, it remains unknown whether and how eNOS-Ser617 phosphorylation is stimulated by shear stress, the primary stimulus of endothelial NO production. This issue was explored in the present study using cultured bovine aortic endothelial cells (BAECs). Over-expression of a constitutively active protein kinase B(Akt) mutant in BAECs increased Ser617 phosphorylation while constitutively active protein kinase A mutant had no effect. When BAECs were subjected to an arterial level of laminar shear stress, eNOS-Ser617 phosphorylation was clearly increased in a time-dependent manner. Shear stress also stimulated Akt phosphorylation at Thr308, one of the key regulatory sites. The time courses of eNOS-Ser617 and Akt-Thr308 phosphorylations appeared to be very similar. These results suggested that eNOS-Ser617 phosphorylation, mediated by Akt, is a physiological response to the mechanical shear stress, involved in the regulation of NO production in endothelial cells.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Independent Regulation of Endothelial Nitric Oxide Synthase by Src and Protein Kinase A in Mouse Aorta Endothelial Cells
Applied Biological Chemistry
2005 .01
-
[P8-11] Biochanin A Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis : Inhibition of Endothelial Cell Survival and Migration by Suppressing the AKT/eNOS Signaling Pathway
한국식품영양과학회 학술대회발표집
2010 .10
-
Optimized phos-tag mobility shift assay for the detection of protein phosphorylation in planta
Journal of Plant Biotechnology
2018 .01
-
[P8-113] A Crude Fraction of Korean Ginseng Extract Stimulates Nitric Oxide Production by Activating Endothelial Nitric Oxide Synthase in Human Umbilical Vein Endothelial Cells
한국식품영양과학회 학술대회발표집
2009 .11
-
Sirt1-Mediated Anti-Aging Effects of Houttuynia cordata Extract in a High Glucose-Induced Endothelial Cell-Aging Model
Preventive Nutrition and Food Science
2020 .03
-
Gingerenone A Attenuates Monocyte-Endothelial Adhesion via Suppression of I Kappa B Kinase Phosphorylation
한국식품영양과학회 학술대회발표집
2016 .10
-
Protopanaxatriol-type of Korean Ginseng Enhances Nitric Oxide Production in Human Endothelial Cells through Pl3K/Akt and AMPK pathways
한국식품영양과학회 학술대회발표집
2011 .10
-
Carnosine inhibits angiogenesis by inhibiting VEGFR-2-mediated ERK/AKT/eNOS signaling pathway
한국식품영양과학회 학술대회발표집
2019 .10
-
Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells
Preventive Nutrition and Food Science
2017 .12
-
Ginsenoside Rg3 from Red Ginseng Prevents Damage of Neuronal Cells Through the Phosphorylation of the Cell Survial Protein Akt
Food Science and Biotechnology
2006 .04
-
Antofine, a Natural Phenanthroindolizidine Alkaloid, Suppresses Angiogenesis via Regulation of AKT/mTOR and AMPK Pathway in Endothelial Cells and Endothelial Progenitor Cells Derived from Mouse Embryonic Stem Cells
한국식품영양과학회 학술대회발표집
2017 .10
-
단식(斷食), 재급식(再給食) 및 인슈린 투여(投與) 후(後)에 쥐의 간(肝)으로부터 분리된 세포핵의 핵단백질 인산화
Applied Biological Chemistry
1980 .01
-
혈관내피세포에서 산양삼 추출물과 진세노사이드 Rg5의 혈관신생 효과
한국식품과학회지
2018 .06
-
Effect of Vascular Endothelial Growth Factor on Porcine In Vitro Maturation
한국수정란이식학회지
2007 .01
-
Conjugated Linoleic Acid (CLA) Inhibits Akt Phosphorylation in HT - 29 Human Colon Cancer Cells : A Mechanism for the Growth Inhibitory Effect of CLA
한국식품영양과학회 학술대회발표집
2004 .11
-
Myricetin Inhibits Angiogenesis by Regulating ROS-Mediated Apoptosis and the PI3K/AKT/mTOR Signaling Pathway in Endothelial Cells.
한국식품영양과학회 학술대회발표집
2017 .10
-
Cytoprotective Effects of Korean Red Ginseng Water Extract on Human Vascular Endothelial Cells
한국식품영양과학회 학술대회발표집
2013 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0