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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.25 No.1
- 발행연도
- 2020.3
- 수록면
- 108 - 112 (5page)
- DOI
- 10.3746/pnf.2020.25.1.108
이용수
초록· 키워드
오류제보하기
Houttuynia cordata (HC) is a herb widely used in traditional Asian medicine as an ingredient in complex prescriptions. HC is known for its anti-leukemic, anti-oxidative, and anti-inflammatory properties. However, its anti-vascular endothelial aging efficacy and the underlying mechanisms are not fully understood. In this study, we investigated the anti-aging effects of HC in a high glucose (HG)-induced endothelial cell (EC)-aging model. Treatment with HC (40㎍/mL) increased migration of ECs, and increased phosphorylation of extracellular signal-regulated kinases and p38 in a dose-dependent manner. Following HG treatment (30 mM), HC significantly decreased the number of senescence-associated β-galactosidase positive cells, which are the biomarkers for aging, in a dose-dependent manner. Based on levels of phosphorylation, HC (40㎍/mL) was shown to increase expression of sirtuin1 (Sirt1) and endothelial nitric oxide synthase (eNOS) by 74.4% and 328.2%, respectively. Furthermore, treatment of HG-induced senescent ECs with HC (40㎍/mL) significantly increased nitric oxide production (P<0.05). These results demonstrate that HC both increases EC migration and regulates the Sirt1/eNOS pathway, suggesting HC has potential for protecting ECs against HG-induced aging.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Chang JS / 2001 / Antileukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb / Am J Chin Med 29:303~312
Hayashi T / 2014 / Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes / Proc Natl Acad Sci USA 111:1168~1173
Hayashi T / 2008 / Nitric oxide and endothelial cellular senescence / Pharmacol Ther 120:333~339
Hsu CC / 2016 / Houttuynia cordata aqueous extract attenuated glycative and oxidative stress in heart and kidney of diabetic mice / Eur J Nutr 55:845~854
Hu T / 2017 / Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic cells from apoptosis / Exp Ther Med 14:1727~1731
Hayashi T / 2014 / Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes / Proc Natl Acad Sci USA 111:1168~1173
Hayashi T / 2008 / Nitric oxide and endothelial cellular senescence / Pharmacol Ther 120:333~339
Hsu CC / 2016 / Houttuynia cordata aqueous extract attenuated glycative and oxidative stress in heart and kidney of diabetic mice / Eur J Nutr 55:845~854
Hu T / 2017 / Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic cells from apoptosis / Exp Ther Med 14:1727~1731
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Influences of N, P₂O₅ and K₂O fertilizer application amounts on growth of Houttuynia cordata Thunb and soil properties
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UCI(KEPA) : I410-ECN-0101-2020-594-000508608