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The effects of higenamine were investigated in the single atrial and ventricular myocyte of the guinea pig by using patch clamp method. The results obtained were as follows: 1) Isoprenaline which is known to be ${\beta}-agonist$ increased the duration of action potential and calcium current in ventricular cells. 2) Higenamine also increased the duration of action potential and calcium current in ventricular myocytes. And its effect was blocked by propranolol. 3) In the atrial cells, isoprenaline showed ${\beta}-agonist$ effects, which were increasing the duration of action potential and calcium current same as in ventricular cells. 4) Higenamine, however, showed the opposite effects of ${\beta}-agonist$ which were decreasing the duration of action potential and calcium current. The above results suggest that higenamine has the typical ${\beta}-agonist$ effect in ventricular cells but inhibitory effect in atrial cells and this effect on atrium could be due to the reduction of calcium current.
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Determination of blood concentration of higenamine by high pressure liquid chromatography
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Heme Oxygenase-l Induction by YS 51, An Analogue of Higenamine, Inhibits Nitric Oxide-Induced Apoptosis of ROS 17/2.8 cells
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[$Cl^-$-sensitive Component of $Ca^{2+}$-activated Tail Current in Rabbit Atrial Myocytes
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