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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Hypersecretion of ACTH in patients with Cushing's syndrome originates from either a pituitary tumor(Cushing's disease) or an ectopic ACTH-secreting tumor. These 2 entities may be clinically indistinguishable, and additional difficulty arise because pituitary microadenomas may be radiologically occult. Recently, bilateral selective venous sampling from the inferior petrosal sinuses became the procedure of choice for confirming a false negative study of a combined hormonal test and pituitary ACTH hypersecretion. We performed selective venous catheterization and smapling for ACTH. The central location of the lesion was detected in 1 case(intersinus gradient=1.1:1), and the remaining 5 cases revealed lateralization of the lesions(intersinus gradient=3.7-20.1:1), which correlated well with transsphenoidal microadenomectomies in all the cases. we concluded that selective venows ACTH sampling from the inferior petroal sinus is a reliable and useful aid in the diagnosis of Cushing's disease when standard clinical and biochemical studies are inconclusive.
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