지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제26권 제12호
- 발행연도
- 2003.1
- 수록면
- 1,074 - 1,078 (5page)
이용수
초록· 키워드
오류제보하기
The effects of glycine on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice was examined. A single administration of morphine (10 mg/kg, s.c.) induced hyperactivity as measured in mice. The morphine-induced hyperactivity was inhibited by pretreatment with glycine (100, 200 and 400 mg/kg, i.p.). In addition, it was found repeated administration of morphine (10 mg/kg, s.c.) to mice daily for 6 days caused an increase in motor activity which could be induced by a subsequent morphine dose, an effect known as reverse tolerance or sensitization. Glycine (100, 200 and 400 rng/kg, i.p.) also inhibited morphine-induced reverse tolerance. Mice that had received 7 daily repeated administrations of morphine also developed postsynaptic dopamine receptor supersensitivity, as shown by enhanced ambulatory activity after administration of apomorphine (2 mg/kg, s.c.). Glycine inhibited the development of postsynaptic dopamine receptor supersensitivity induced by repeated administration of morphine. It is suggested that the inhibitory effects of glycine might be mediated by dopaminergic (DAergic) transmission. Accordingly, the inhibition by glycine of the morphine-induced hyperactivity, reverse tolerance and dopamine receptor supersensitivity suggests that glycine might be useful for the treatment of morphine addiction.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Inhibition of glycine on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice
대한약학회 학술대회
2003 .01
-
Inhibition of THIP on Morphine-Induced Hyperactivity, Reverse Tolerance and Postsynaptic Dopamine Receptor Supersensitivity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
GABA-gated chloride channels modulate morphine-induced hyperactivity, reverse tolerance and dopamine receptor supersensitivity
대한약학회 학술대회
2001 .01
-
Effects of Glycine on the Development of Analgesic Tolerance to and Physical Dependence on Morphine in Mice
Toxicological Research
2003 .12
-
Effects of glycine on the development of tolerance to and physical dependence on morphine in mice
대한약학회 학술대회
2003 .01
-
Inhibition by MK-801 of Morphine-Induced Conditioned Place Preference and Postsynaptic Dopamine Receptor Supersensitivity in Mice
한국응용약물학회 춘계학술발표논문집
1996 .01
-
Inhibitory Effects of (-)-Epigallocatechin gallate on Morphine-Induced Locomotor Sensitization and Conditioned Place Preference in Mice
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2006 .01
-
Effects of adenosine on the development of tolerance to and physical dependence on morphine in mice
대한약학회 학술대회
2003 .01
-
코카인으로 유도된 행동과다 , 역내성 및 Dopamine 수용체 초과민성에 미치는 인삼 Saponin의 효과 ( Effects of Ginseng Saponins on Cocaine-Induced Hyperactivity , Reverse Tolerance and Dopamine Receptor Supersensitivity in Mice )
Journal of Ginseng Research
1995 .08
-
Limonene Inhibits Methamphetamine-Induced Sensitizations via the Regulation of Dopamine Receptor Supersensitivity
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Protective Effects of Panax ginsengon the Neurotoxicity Induced by Abuse Drugs
고려인삼학회 학술대회
2005 .11
-
모르핀의 내성 및 의존성 형성에 미치는 인삼의 효과(I) -마우스에 대한 인삼 부탄올 분획의 영향-
약학회지
1985 .01
-
changes in dopamine receptor binding by mk-801 in morphine - dependent rats
한국독성학회지
1998 .03
-
Effects of Morphine and Panax ginseng on the Opioid Receptor-G protein Interactions
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1999 .01
-
Effects of cholane compounds on the development of morphine tolerance
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1990 .01
-
Inhibitory Effects of Paeonol on Morphine-Induced Locomotor Sensitization and Conditioned Place Preference in Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Effects of Ginseng Saponins on Morphine 6-Dehydrogenase
한국응용약물학회 춘계학술발표논문집
1994 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0