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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 357 - 362 (6page)
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초록· 키워드
오류제보하기
Limonene is a cyclic terpene found in citrus essential oils and inhibits methamphetamine- induced locomotor activity. Drug dependence is a severe neuropsychiatric condition that depends in part on changes in neurotransmission and neuroadaptation, induced by exposure to recreational drugs such as morphine and methamphetamine. In this study, we investigated the effects of limonene on the psychological dependence induced by drug abuse. The development of sensitization, dopamine receptor supersensitivity, and conditioned place preferences in rats was measured following administration of limonene (10 or 20 mg/kg) and methamphetamine (1 mg/kg) for 4 days. Limonene inhibits methamphetamine- induced sensitization to locomotor activity. Expression of dopamine receptor supersensitivity induced by apomorphine, a dopamine receptor agonist, was significantly reduced in limonenepretreated rats. However, there was no significant difference in methamphetamine-induced conditioned place preferences between the limonene and control groups. These results suggest that limonene may ameliorate drug addiction-related behaviors by regulating postsynaptic dopamine receptor supersensitivity.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Allen RM / 1978 / Phencyclidine-induced psychosis / Am. J. Psychiatry 135:1081~1084
Bello EP / 2011 / Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors / Nat Neurosci 14:1033~1038
Bhargava HN / 1980 / Cyclo(leucylglycine)inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats / Life Sci 27:117~123
Blander A / 1984 / Conditioned place preference : an evaluation of morphine’s positive reinforcing properties / Psychopharmacology 84:124~127
Bozarth MA / 1981 / Heroin reward is dependent on a dopaminergic substrate / Life Sci 29:1881~1886
Bello EP / 2011 / Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors / Nat Neurosci 14:1033~1038
Bhargava HN / 1980 / Cyclo(leucylglycine)inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats / Life Sci 27:117~123
Blander A / 1984 / Conditioned place preference : an evaluation of morphine’s positive reinforcing properties / Psychopharmacology 84:124~127
Bozarth MA / 1981 / Heroin reward is dependent on a dopaminergic substrate / Life Sci 29:1881~1886
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