Epidermal Growth Factor Induces Vasoconstriction Through the Phosphatidylinositol 3-Kinase-Mediated Mitogen-Activated Protein Kinase Pathway in Hypertensive Rats

Kim, Jung-Hwan; Lee, Chang-Kwon; Park, Hyo-Jun; Kim, Hyo-Jin; So, Hyun-Ha; Lee, Keun-Sang; Lee, Hwan-Myung; Roh, Hui-Yul; Choi, Wahn-Soo; Park, Tae-Kyu; Kim, Bo-Kyung

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자료유형: 학술저널

저자정보: Kim, Jung-Hwan (Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology) Lee, Chang-Kwon (Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology) Park, Hyo-Jun (Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology) Kim, Hyo-Jin (Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology) So, Hyun-Ha (Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology) Lee, Keun-Sang (Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology) Lee, Hwan-Myung (Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology) Roh, Hui-Yul (Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology) Choi, Wahn-Soo (Department of Immunology, College of Medicine, Institute of Biomedical Science and Technology) Park, Tae-Kyu (Department of Biotechnology, College of Biomedical & Health Science, Konkuk University) Kim, Bo-Kyung (Department of Physiology, College of Medicine,)

저널정보: 대한물리치료과학회 대한물리치료사학회지 대한물리치료사학회지 제13권 제2호

발행연도: 2006.1

수록면: 137 - 145 (9page)

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We investigated whether increased contractile responsiveness to epidermal growth factor (EGF) is associated with altered activation of mitogen-activated protein kinase (MAPK) in the aortic smooth muscle of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. EGF induced contraction and MAPK activity in aortic smooth muscle strips, which were significantly increased in tissues from the DOCA-salt hypertensive rats compared with those from sham-operated rats. AG1478, PD98059, and LY294002, inhibitors of EGF receptor (EGFR) tyrosine kinase, MAPK/extracellular signal-regulated kinase (ERK) kinase, and phosphatidylinositol 3-kinase (PI3K), respectively, inhibited the contraction and the activity of ERK1/2 that were elevated by EGF. Y27632 and GF109203X, inhibitors of Rho kinase and protein kinase C, respectively, attenuated EGF-induced contraction, with no diminution of ERK1/2 activity. Although EGF also elevated the activity of EGFR tyrosine kinase in both sham-operated and DOCA-salt hypertensive rats, the expression and the magnitude of activation did not differ between strips. These results strongly suggest that EGF induces contraction by the activation of ERK1/2, which is regulated by the PI3K pathway in the aortic smooth muscle of DOCA-salt hypertensive rats.

#epidermal growth factor #hypertension #vasoconstriction #mitogen-activated protein kinase #phosphatidylinositol 3-kinase

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소속기관 용인대학교 물리치료학과

주요연구분야 의약학 > 임상의학 > 물리치료학

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Lee, Chang-Kwon