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자료유형
학술저널
저자정보
Ryu, Je-Il (Departments of Neurosurgery, School of Medicine, Hanyang University) Kim, Choong-Hyun (Departments of Neurosurgery, School of Medicine, Hanyang University) Cheong, Jin-Hwan (Departments of Neurosurgery, School of Medicine, Hanyang University) Bak, Koang-Hum (Departments of Neurosurgery, School of Medicine, Hanyang University) Kim, Jae-Min (Departments of Neurosurgery, School of Medicine, Hanyang University) Oh, Suck-Jun (Departments of Neurosurgery, School of Medicine, Hanyang University)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제40권 제1호
발행연도
2006.1
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1 - 5 (5page)

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Objective : Survivin is an inhibitor of apoptosis protein[IAP], which inhibits apoptosis through a pathway distinct from the Bcl-2 family members. Overexpression of survivin and Bcl-2 have been commonly reported in human neoplasms. The authors investigate whether there is a synergistic effect on the anti-apoptosis rate of primary brain tumors "in situ" based on the co-expression of survivin and Bcl-2. Methods : One hundred and two brain tumor patients who had been resected were included in this study. Survivin tin and Bcl-2 were detected by Western blotting analysis, while apoptosis was examined by DNA fragmentation analysis. An anti-apoptotic rate was assessed in these brain tumor samples based on the expression of survivin and Bcl-2 or co-expression of both. Results : Survivin and Bcl-2 were expressed in 57[55.9%] and 53[52.0%] of 102 brain tumor samples studied respectively, and co-expressed in 31[30.4%]. The percentage of astrocytic and meningeal tumors expressing survivin was significantly correlated with histological grades; however, Bcl-2 was not correlated [p=0.106]. The anti-apoptotic rate in primary brain tumors with survivin, Bcl-2, and both was detected in 49[86.0%] of 57 samples, 42[79.9%] of 53 samples, and 27[87.1%] of 31 samples, respectively. Their difference in the frequency of anti-apoptosis was not significant. Conclusion : Survivin or Bcl-2 is involved in the anti-apoptosis. However, it suggests that co-expression of survivin and Bcl-2, together, have no synergistic effect on the anti-apoptotic properties of the primary brain tumors.

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