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논문 기본 정보

자료유형
학술저널
저자정보
Cho, Nam-Jin (College of Pharmacy, Seoul National University) Sung, Sang-Hyun (College of Pharmacy, Seoul National University) Lee, Heum-Sook (Department of Food Science & Technology, Seoul National Polytechnic University) Jeon, Mee-Hee (Korea and Ministry of Health and Welfare, Central Pharmaceutical Affairs Council) Kim, Young-Choong (College of Pharmacy, Seoul National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제18권 제4호
발행연도
1995.1
수록면
289 - 292 (4page)

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Icariside II, a flavonol glycoside, was isolated from the aerial part of Epimedium Koreanum Nakai by the anti-hepatotoxic acitivity guided fractionation technique employing $CCl_4-in-toxicated$ primary cultured rat hepatocytes as an assay system. Its anti-hepatotoxic activity was evaluated by measuring activity of glutamic pyruvic transaminase released from the $CCl_4-in-toxicated$ primary cultured rat hapatocytes. Icariside II significantly reduced the activity of glutamic pyruvic transaminase released from the $CCl_4-in-toxicated$ primary cultured rat hepatocytes and resulted in 78% recovery of the toxicity at the concentration of $200{\;}\mu\textrm{m}$. The anti-hepatotoxic activity of icariside II on the $CCl_4-in-toxicated$ primary cultured rat hepatocytes was as potent as that of silybin.

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