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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 47 - 53 (7page)
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Objectives : This study was performed to investigate the anti-diabetic effect of the fruit extract of Lycium chinense Mill(Lycii Fructus, LF) on multiple low-dose streptozotocin-induced diabetic rats.Methods : Male Sprague-Dawley rats were divided into three groups; normal, STZ-control, Lycii Fructus extractorally administrated 300 ㎎/㎏ group (STZ-LF). Diabetes was induced in rats by consecutive injection of streptozotocin (STZ) at doses of 30 ㎎/㎏ for 5 days. After 4 weeks, all rats were sacrificed, Fasting blood glucose, total cholesterol (CHO), triglyceride (TG) and HDL-Cholesterol were measured in sera of rats. Histopathological changes of pancreas, kidney, liver and lung tissues were observed by microscope after H&E, Periodic acid-Schiff (PAS) and Masson's trichrome staining. The changes of body weight, blood glucose, and food and water intake were also measured.Results : There were no differences in body, food intake and water intake in LF-administrated groups compared with STZ control group. However, LF extract significantly decreased the levels of serum glucose, CHO, TG and HDL-Cholesterol in diabetic rats. In histopathological analysis of kidney, liver and lung, LF-administrated groups showed the inhibition of morphological damage.Conclusions : These results suggest that LF have a biological action on multi low-dose STZ-induced diabetes in rats via decreasing the serum glucose, TG and TG levels and may protect the morphological changes of kidney, liver and lung.
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참고문헌 (28)
참고문헌 신청
Nepom GT / 1990 / A unified hypothesis for the complex genetics of HLA associations with IDDM / Diabetes 39(10):1153~1157
Im JI / 2003 / Recent trends in diabetes research / Health Industry Technology Trends 1:28~38
DeFronzo RA / 1991 / Insulin resistance - a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease / Diabetes Care 14:173~194
Textbook of Neuropsychiatry, College of Oriental Medicine / 2010 / Supplementary hanuisin new science / Jipmundang :332~341
Sunil C / 2012 / Antidiabetic effect of plumbagin isolated from Plum-bago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats / Food Chem Toxicol 50(12):4356~4363
Im JI / 2003 / Recent trends in diabetes research / Health Industry Technology Trends 1:28~38
DeFronzo RA / 1991 / Insulin resistance - a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease / Diabetes Care 14:173~194
Textbook of Neuropsychiatry, College of Oriental Medicine / 2010 / Supplementary hanuisin new science / Jipmundang :332~341
Sunil C / 2012 / Antidiabetic effect of plumbagin isolated from Plum-bago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats / Food Chem Toxicol 50(12):4356~4363
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