지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 338 - 342 (5page)
이용수
초록· 키워드
오류제보하기
The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Following 24-week treatment, response thresholds to four different stimuli were tested and found to be lower in diabetic rats than in normal rats. Empagliflozin significantly prevented hypersensitivity (P<0.05) and the loss of skin intraepidermal nerve fibers, and mesangial matrix expansion in diabetic rats. Results of this study demonstrate the potential therapeutic effects of empagliflozin for the treatment of diabetic peripheral neuropathy and nephropathy.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
정창희 / 2014 / A Novel Therapeutic Agent for Type 2 Diabetes Mellitus: SGLT2 Inhibitor / Diabetes and Metabolism Journal 38(4):261~273
Ahmadieh H / 2017 / Role of sodium glucose cotransporter-2 inhibitors in type I diabetes mellitus / Diabetes Metab Syndr Obes 10:161~167
Takakura S / 2016 / Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats / Life Sci 147:125~131
Neumiller JJ / 2014 / Empagliflozin: a new sodium-glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes / Drugs Context 3:212262
Asensio-Pinilla E / 2009 / Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury / Exp Neurol 219:258~265
Ahmadieh H / 2017 / Role of sodium glucose cotransporter-2 inhibitors in type I diabetes mellitus / Diabetes Metab Syndr Obes 10:161~167
Takakura S / 2016 / Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats / Life Sci 147:125~131
Neumiller JJ / 2014 / Empagliflozin: a new sodium-glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes / Drugs Context 3:212262
Asensio-Pinilla E / 2009 / Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury / Exp Neurol 219:258~265
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Influence of Glucose Fluctuation on Peripheral Nerve Damage in Streptozotocin-Induced Diabetic Rats
Diabetes and Metabolism Journal
2022 .01
-
Effects of Exercise on Neuropathy in Streptozotocin-Induced Diabetic Rats
Annals of Rehabilitation Medicine
2017 .06
-
A New Rat Model of Cisplatin-induced Neuropathic Pain
The Korean Journal of Pain
2015 .01
-
COVID-19 Rapid Antigen Test Results in Preschool and School (March 2 to May 1, 2022)
Pediatric Infection and Vaccine
2024 .04
-
Impact of polystyrene microplastic exposure on lipid profile and oxidative stress status of male and female Wistar rats
Environmental Analysis Health and Toxicology
2022 .09
-
Streptozotocin으로 유도된 당뇨 랫드에서 황칠나무 잎 열수추출물의 항당뇨 효과
Korean Journal of Veterinary Research(대한수의학회지)
2021 .12
-
Increased Nociceptive Responses in Streptozotocin- Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-Methyl-D-Aspartate Receptors
Diabetes and Metabolism Journal
2019 .01
-
Anti-Diabetic Effects of an Ethanol Extract of Cassia Abbreviata Stem Bark on Diabetic Rats and Possible Mechanism of Its Action - Anti-diabetic Properties of Cassia abbreviata -
Journal of Pharmacopuncture
2017 .01
-
Effect of fermented bean complex with korean medicinal herbs on blood glucose levels and histomorphology in type I diabetic rat models
한국실험동물학회 학술발표대회 논문집
2022 .01
-
The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats
The Korean Journal of Physiology & Pharmacology
2018 .09
-
Streptozotocin 저용량 반복투여로 유도한 당뇨 흰쥐에서 구기자 추출물의 효능연구
대한본초학회지(본초분과학회지)
2015 .01
-
하고초 추출물의 streptozotocin 유발 당뇨 랫트 사구체 손상 개선 효과
동의생리병리학회지
2017 .10
-
Effect of edaravone in diabetes mellitus-induced nephropathy in rats
The Korean Journal of Physiology & Pharmacology
2016 .07
-
Effects of Aging on Angiogenic and Muscle Growth-Related Factors in Naturally Aged Rat Skeletal Muscles
Annals of geriatric medicine and research
2020 .01
-
Attenuation of Diabetic Conditions by Sida rhombifolia in Moderately Diabetic Rats and Inability to Produce Similar Effects in Severely Diabetic in Rats
Journal of Pharmacopuncture
2015 .01
-
Combination of Metformin and Epigallocatechin-3-Gallate Lowers Cortisol, 11β-Hydroxysteroid Dehydrogenase Type 1, and Blood Glucose Levels in Sprague Dawley Rats with Obesity and Diabetes
Journal of Obesity & Metabolic Syndrome
2024 .09
-
Evaluation of 28-day repeated oral dose toxicity of aluminum chloride in rats
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Evaluation of 28-day repeated oral dose toxicity of aluminum chloride in rats
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Modulation of Inflammatory Cytokines and Islet Morphology as Therapeutic Mechanisms of Basella alba in Streptozotocin-Induced Diabetic Rats
Toxicological Research
2018 .10
-
Direct vascular actions of quercetin in aorta from renal hypertensive rats
Kidney Research and Clinical Practice
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0