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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 25 - 30 (6page)
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초록· 키워드
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Objectives : Laver (Porphyra tenera), a red algae species, is one of the most widely consumed edible seaweed in Korea. Laver contains various substances such as essential amino acid, fiber, minerals and polyphenols that benefit human health. In the present study, we prepared ethanol extracts from commercially processed product of Porphyra tenera, and evaluated the growth inhibitory effect against human oral squamous carcinoma YD-10B cells. Methods : Cell viability was measured by MTT assay. Apoptosis was confirmed by TUNEL assay and flow cytometry with the green fluorescent dye FITC annexin V entering apoptotic cells and the red fluorescent dye PI not entering. The expression of the relevant proteins was detected using Western blot. Results : Ethanol extracts of Porphyra tenera (PTE, $50-200{\mu}g/m{\ell}$) caused a significant decrease of cell viability in a dose dependant manner. The cell death occurred as a result of apoptotic process as determined by TUNEL assay and flow cytometric analysis. In line with this observation, decrease in procaspase proteins and increase in cytosolic cytochrome c were observed in cells treated with PTE. In addition, exposure to PTE decreased the expression levels of Bcl-2, and induced PARP cleavage and AIF translocation from mitochondria to nucleus. Conclusions : In conclusion, PTE exerts anti-cancer effects by inducing apoptosis via caspase activation and AIF nuclear translocation in YD-10B cells. These results provide evidence for the possible therapeutic effect of Porphyra tenera in oral cancer cells.
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참고문헌 (17)
참고문헌 신청
Jimenez-Escrig A / 1999 / Nutritional evaluation and physiological effects of edible seaweeds / Arch Latinoam Nutr 49(2):114~120
The korean association of university professors of herbology / 1992 / Herbology / Younglimsa :471~474
Park CK / 2000 / The nutritional and functional constituents of laver / Bull Fish Sci Inst Yosu Nat'l Univ 9:133~137
김동균 / 2013 / 해조류 6종의 생화학적 조성 및 영양적 가치 분석 / 생명과학회지 23(8):1004~1009
Lee HS / 1996 / A Study on the development of high-fiber supplements for the diabetic patients - Effect of seaweed supplementation on the lipid and glucose metabolism in streptozotocin-induced diabetic rats / Korean J Nutr 29(3):296~306
The korean association of university professors of herbology / 1992 / Herbology / Younglimsa :471~474
Park CK / 2000 / The nutritional and functional constituents of laver / Bull Fish Sci Inst Yosu Nat'l Univ 9:133~137
김동균 / 2013 / 해조류 6종의 생화학적 조성 및 영양적 가치 분석 / 생명과학회지 23(8):1004~1009
Lee HS / 1996 / A Study on the development of high-fiber supplements for the diabetic patients - Effect of seaweed supplementation on the lipid and glucose metabolism in streptozotocin-induced diabetic rats / Korean J Nutr 29(3):296~306
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