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Objectives: Erigeron bonariensis is a type of Erigeron found throughout the tropical and subtropical areas as one of the perennial plants or pioneer plants. It is known to show detoxifying, antipyretic, and anticancer effects for various cancers. However, there are no reports on the anticancer effect of E. bonariensis on oral cancer cells. In the present study, we investigated the effects of the methanol extract of Erigeron bonariensis (MEEB) on the inhibition of cell growth and induction of apoptosis in mucoepidermoid carcinoma (MEC) cell lines, including the MC3 and YD15 oral cancer cells. Methods: MC3 Cells were treated by dimethyl sulfoxide (DMSO) or methanol extracts of 20 various natural products 20 μg/mL for 48 hours and cell viability were analyzed as Trypan blue exclusion assay. The effects of MEEB treatment on the cell viability of MC3 and YD15 cells, for 48 h, were analyzed by Trypan blue exclusion assay. The anticancer efficacy and apoptosis of oral cancer cell lines were analyzed by western blot analysis. The statistical significance of differences between groups was analyzed by Student’s two-tailed t-test. A value of P<0.05 compared to the vehicle control was considered statistically significant. Results: Among 20 different naturally derived products, MEEB significantly inhibited cell viability and increased cleaved poly [ADP-ribose] polymerase 1 (PARP) protein in the MC3 and YD15 cells in a concentration-dependent manner. Conclusions: These results suggest that MEEB can be used as a natural anticancer drug for the treatment of human oral cancer.
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참고문헌 (25)
참고문헌 신청
Warnakulasuriya S / 2009 / Global epidemiology of oral and oropharyngeal cancer / Oral Oncol 45(4-5):309~316
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008 : GLOBOCAN 2008 / Int J Cancer 127(12):2893~2917
조경화 / 2017 / Lysophosphatidic Acid-Induced TWIST1 and Slug Expression in Oral Cancer Cell Invasion / 치위생과학회지 17(5):433~438
Choi ES / 2017 / Silymarin and its active component silibinin act as novel therapeutic alternatives for salivary gland cancer by targeting the ERK1/2-Bim signaling cascade / Cell Oncol(Dordr) 40(3):235~246
Lujan B / 2010 / Activation of the EGFR/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands / Br J Cancer 103(4):510~516
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008 : GLOBOCAN 2008 / Int J Cancer 127(12):2893~2917
조경화 / 2017 / Lysophosphatidic Acid-Induced TWIST1 and Slug Expression in Oral Cancer Cell Invasion / 치위생과학회지 17(5):433~438
Choi ES / 2017 / Silymarin and its active component silibinin act as novel therapeutic alternatives for salivary gland cancer by targeting the ERK1/2-Bim signaling cascade / Cell Oncol(Dordr) 40(3):235~246
Lujan B / 2010 / Activation of the EGFR/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands / Br J Cancer 103(4):510~516
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