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논문 기본 정보

자료유형
학술저널
저자정보
Ha, Yeong Su (Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine) Kwak, Wonjung (Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine) Lee, Hwa Young (Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine) Lee, Byung-Heon (Department of Biochemistry and Cell Biology and Cell & Matrix Research Institute, Kyungpook National University School of Medicine) Hong, Il-Hwa (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) Jeong, Kyu-Shik (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) An, Gwang Il (Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences Seoul) Yoo, Jeongsoo (Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine)
저널정보
대한방사성의약품학회 대한방사성의약품학회지 대한방사성의약품학회지 제1권 제1호
발행연도
2015.1
수록면
38 - 45 (8page)

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Most tumors are believed to overexpress several receptors, and small peptides targeting these receptors were developed for diagnosis and tumor therapy during past decade. Here we report that fibroadenoma can be visualized by bladder cancer specific peptide. A 9-mer bladder cancer specific peptide, which was discovered from the phage display method, was synthesized by peptide synthesizer, and additional tyrosine was conjugated at the N-terminal for radioiodination (Y-BP). Y-BP was radiolabeled with $^{131/124}I$ using Iodogen tube. The rat treated with N-butyl-N-(4-hydroxybutyl)nitrosamine for 8 weeks was allowed to grow until large size tumor was developed under axilla. The tumor model was microPET imaged sequentially using [$^{18}F$]FDG and radioiodinated $^{124}I-Y-BP$. The tumor was excised and examined by immunostaining studies. Radioiodinated $^{124}I-Y-BP$ was purified using fast protein liquid chromatography (FPLC) in > 90% radiochemical purity. The whole tumor was well visualized by [$^{18}F$]FDG with several intense focal uptake within tumor. The tumor was also clearly seen with $^{124}I-Y-BP$ at 4 h post-injection, and to our surprise the tumor uptake of $^{124}I-Y-BP$ lasted up to three days. The tumor was diagnosed histologically as a fibroadenoma derived from mammary gland. In conclusion, the bladder cancer specific peptide showed the good potential as a new radiotracer for the detection of breast fibroadenoma.
#Bladder cancer specific peptide #Fibroadenoma #PET imaging #Imaging agent #Radiopharmaceuticals

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참고문헌 (25)

참고문헌 신청
Lim WK / 2014 / Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma / Nat Genet 46:877~880 google schola Won KS / 2007 / Juvenile fibroadenoma of the breast demonstrated on 111In-octreotide SPECT and 18F-FDG PET/CT / Eur J Nucl Med Mol Imaging 34:440 google schola Krishnamurthy S / 2000 / Distinction of phyllodes tumor from fibroadenoma: a reappraisal of an old problem / Cancer 90:342~349 google schola Pietruszka M / 1978 / Cystosarcoma phyllodes: a clinicopathologic analysis of 42 cases / Cancer 41:1974~1983 google schola Norris HJ / 1967 / Relationship of histologic features to behavior of cystosarcoma phyllodes. Analysis of ninety-four cases / Cancer 20:2090~2099 google schola

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