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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 139 - 148 (10page)
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초록· 키워드
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Objectives : This study was performed to examine the toxicity on the long term procedure of Aconitum ciliare Decaisne pharmacopuncture(ADP) solution. Methods : To evaluate the long term toxicity of 3 different repeated doses, 60, 150, and 300 mg/kg/day for 13 weeks were injected into BALB/c mice, respectively. The ADP solution was injected into near ST36 of the right leg and normal saline of the same volume was used for the vehicle control group. To evaluate the toxicity of 60, 150, and 300 mg/kg of repeated doses for 13 weeks, toxic symptoms, weight measurement, hematological test, blood biochemical test, visual examination and weight measurement of major organs, and histopathological test were conducted. Results : No significant changes in toxic symptoms, weight measurement, hematological test, blood biochemical test, visual examination and weight measurement of major organs, and histopathological test were observed in different doses of ADP solution treated groups compared to vehicle control group. Conclusions : As a result, repeated dose at a concentration of 300 mg/kg or less is considered to be not harmful for clinical treatment.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Lee DH / 2009 / The study on Experimental Protocols for Safety Evaluation of Pediatric Drugs
장인수 / 2007 / 최근 독성 문제가 제기된 한약재에 대한 고찰 / 대한한의학회지 28(1):1~10
양가람 / 2009 / Effect of Snake Venom Toxin from Vipera lebetina turanica on Breast Cancer Cells / Journal of Acupuncture Research 26(3):27~38
오명진 / 2012 / Inhibitory Effect of Snake Venom on Colon Cancer Cell Growth Through Induction of Death Receptor Dependent Apoptosis / Journal of Acupuncture Research 29(1):25~35
이병춘 / 2012 / Effect of Snake Venom on Cancer Growth through Induction of Apoptosis via Down Regulation of NF-κB and STAT3 in the PA-1, Ovarian Cancer Cells / Journal of Acupuncture Research 29(1):37~45
장인수 / 2007 / 최근 독성 문제가 제기된 한약재에 대한 고찰 / 대한한의학회지 28(1):1~10
양가람 / 2009 / Effect of Snake Venom Toxin from Vipera lebetina turanica on Breast Cancer Cells / Journal of Acupuncture Research 26(3):27~38
오명진 / 2012 / Inhibitory Effect of Snake Venom on Colon Cancer Cell Growth Through Induction of Death Receptor Dependent Apoptosis / Journal of Acupuncture Research 29(1):25~35
이병춘 / 2012 / Effect of Snake Venom on Cancer Growth through Induction of Apoptosis via Down Regulation of NF-κB and STAT3 in the PA-1, Ovarian Cancer Cells / Journal of Acupuncture Research 29(1):37~45
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