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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 133 - 136 (4page)
- DOI
- https://doi.org/10.13041/jpvm.2017.41.3.133
이용수
초록· 키워드
오류제보하기
This study examined the acute toxicity of Vital-Shoot containing reduced glutathione in male and female ICR mice.
Mice were intraperitoneally injected the drug at dose levels of 0, 250, 500, 1,000 and 2,000 mg/kg body weight (BW) for single-dose toxicity test. There were no significant differences in BW changes between the control and all treated groups.
Based on hematological and blood biochemical analysis, none of the parameters were affected by the drug. Similarly, there were no significant effects on markers for liver and kidney functions in any treated groups. Since there were no adverse effects from the drug in a single-dose intraperitoneal toxicity test, even at higher doses than normal, it was concluded that the lethal dose 50 (LD50) of Vital-Shoot is estimated to be >2,000 mg/kg BW.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Abuelo A / 2013 / Oxidative stress index (OSI) as a new tool to assess redox status in dairy cattle during the transition period / Animal 7:1374~1378
Animal and Plant Quarantine Agency / 2009 / Notification 2009-18. The guideline for toxicity studies of animal medicinal drugs / APFQIA :4~5
Bélanger M / 2011 / Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation / Cell Metab 14:724~738
조주현 / 2011 / Single- and repeated-dose toxicities of aloe fermentation products in rats / Laboratory Animal Research 27(3):235~244
Fulda S / 2010 / Cellular stress responses: cell survival and cell death / Int J Cell Biol 2010:214074
Animal and Plant Quarantine Agency / 2009 / Notification 2009-18. The guideline for toxicity studies of animal medicinal drugs / APFQIA :4~5
Bélanger M / 2011 / Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation / Cell Metab 14:724~738
조주현 / 2011 / Single- and repeated-dose toxicities of aloe fermentation products in rats / Laboratory Animal Research 27(3):235~244
Fulda S / 2010 / Cellular stress responses: cell survival and cell death / Int J Cell Biol 2010:214074
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