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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제9호
- 발행연도
- 2008.1
- 수록면
- 1,187 - 1,194 (8page)
이용수
초록· 키워드
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trans-Stilbenes induce cytochrome P450 1B1 (CYP1B1) inhibition and cell death. 2,4,3',5'tetramethoxystilbene (TMS), a synthetic trans-stilbene analog, induced apoptotic cell death in PC-3 prostate cancer cells, as evidenced by a decrease in the mitochondrial membrane potential. TMS-induced apoptosis was associated with an increase in the level of cell cycle inhibitor, $p27^{kip1}$, through reduction of Akt-mediated Skp2 expression. TMS-induced activation of protein phosphatase 2A (PP2A) inhibited Akt phosphorylation and $p27^{kip1}$ expression, indicating that PP2A is involved in the induction of $p27^{kip1}$ via Akt inhibition. These results suggest that TMS may inhibit the cell cycle through induction of $p27^{kip1}$, leading to apoptotic cell death in PC-3 prostate cancer cells.
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