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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제3호
- 발행연도
- 2019.1
- 수록면
- 171 - 179 (9page)
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초록· 키워드
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Pituitary tumors are usually benign but can occasionally exhibit hormonal and proliferative behaviors. Dysregulation of the G1/S restriction point largely contributes to the over-proliferation of pituitary tumor cells. F-box protein S-phase kinase-interacting protein-2 (SKP2) reportedly targets and inhibits the expression of p27Kip1, a well-known negative regulator of G1 cell cycle progression. In this study, SKP2 expression was found to be upregulated while p27Kip1 expression was determined to be downregulated in rat and human pituitary tumor cells. Furthermore, SKP2 knockdown induced upregulation of p27Kip1 and cell growth inhibition in rat and human pituitary tumor cells, while SKP2overexpression elicited opposite effects on p27Kip1 expression and cell growth. The expression of microRNA-186 (miR-186) was reported to be reduced in pituitary tumors. Online tools predicted SKP2 to be a direct downstream target of miR-186, which was further confirmed by luciferase reporter gene assays. Moreover, miR-186 could modulate the cell proliferation and p27Kip1-mediated cell cycle alternation of rat and human pituitary tumor cells through SKP2. As further confirmation of these findings, miR-186 and p27Kip1 expression were downregulated, while SKP2 expression was upregulated in human pituitary tumor tissue samples; thus, SKP2 expression negatively correlated with miR-186 and p27Kip1 expression. In contrast, miR-186 expression positively associated with p27Kip1 expression. Taken together, we discovered a novel mechanism by which miR-186/SKP2 axis modulates pituitary tumor cell proliferation through p27Kip1-mediated cell cycle alternation.
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참고문헌 (37)
참고문헌 신청
Shimon I / 1997 / Genetic basis of endocrine disease : pituitary tumor pathogenesis / J Clin Endocrinol Metab 82:1675~1681
Coire CI / 1997 / Cushing’s syndrome from an ectopic pituitary adenoma with peliosis : a histological, immunohistochemical, and ultrastructural study and review of the literature / Endocr Pathol 8:65~74
Asa SL / 1998 / The cytogenesis and pathogenesis of pituitary adenomas / Endocr Rev 19:798~827
Palumbo T / 2013 / Functional screen analysis reveals miR-26b and miR-128as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN-AKT pathway / Oncogene 32:1651~1659
Tang FY / 2008 / Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway / Mol Nutr Food Res 52:646~654
Coire CI / 1997 / Cushing’s syndrome from an ectopic pituitary adenoma with peliosis : a histological, immunohistochemical, and ultrastructural study and review of the literature / Endocr Pathol 8:65~74
Asa SL / 1998 / The cytogenesis and pathogenesis of pituitary adenomas / Endocr Rev 19:798~827
Palumbo T / 2013 / Functional screen analysis reveals miR-26b and miR-128as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN-AKT pathway / Oncogene 32:1651~1659
Tang FY / 2008 / Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway / Mol Nutr Food Res 52:646~654
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