지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Effects of citrate-capped silver nanoparticles (AgNPs) on the blood coagulation and platelet aggregation were investigated using whole blood, platelet rich plasma (PRP) and washed platelet obtained from SD male rats. To confirm the stability of AgNPs in the test, size distribution of the nanoparticles was measured in the vehicles including distilled water, serum, and platelet buffers. The average size of AgNPs was 20 nm in the vehicles, which means that the stability was maintained during the whole experimental period. When blood coagulation was monitored by using whole blood impedance aggregometer, coagulation was not observed at the concentration of 1, 10 and 50 ppm. Platelets in plasma or in buffer were not aggregated by AgNPs at the concentration of 1, 2 and 4 ppm, respectively. The test concentration of AgNPs could not be increased because the dark color of the nanoparticles impeded the transmission of light, which is an indicator of aggregation. Although the blood or platelets were pre-activated by collagen, thrombin, or ADP with sub-threshold level, aggregation was not observed at the test concentration. Microscopic observation also supported the result obtained by the aggregometer.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
de Lima, R. / 2012 / Silver nanoparticles: a brief review of cytotoxicity and genotoxicity of chemically and biogenically synthesized nanoparticles / J. Appl. Toxicol 32:867
Marambio-Jones, C. / 2010 / A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment / J. Nanopart. Res 12:1531
Mukherjee, S. G. / 2012 / Comparative in vitro cytotoxicity study of silver nanoparticle on two mammalian cell lines / Toxicol. In Vitro 26:238
Li, Y. / 2011 / Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay / Mutat. Res 745:4
Suresh, A. K. / 2012 / Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types / Langmuir 28:2727
Marambio-Jones, C. / 2010 / A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment / J. Nanopart. Res 12:1531
Mukherjee, S. G. / 2012 / Comparative in vitro cytotoxicity study of silver nanoparticle on two mammalian cell lines / Toxicol. In Vitro 26:238
Li, Y. / 2011 / Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay / Mutat. Res 745:4
Suresh, A. K. / 2012 / Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types / Langmuir 28:2727
이 논문의 저자 정보
최근 본 자료
댓글(0)
0