지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The aim of the present study is to investigate the anti-inflammatory effect of a Rice Bran Ethanol Extract (RBE). Inflammation, such as a bacterial infection in vivo metabolites, such as external stimuli or internal stimuli to the defense mechanisms of the biological tissue a variety of intracellular regulatory factors deulin inflammatory TNF-${\alpha}$, IL-$1{\beta}$, IL-6, IL-8, such as proinflammatory cytokines, prostagrandin, lysosomal enzyme, free radicals are involved in a variety of mediators. The present study was designed to determine the effect of the RBE on pro-inflammatory factors such as NO, iNOS expression and TNF-${\alpha}$, IL-$1{\beta}$, IL-6 in lipopolysaccharide (LPS) - stimulated RAW264.7 macrophages cells. The cell toxicity was determined by MTS assay. To evaluate of anti-inflammatory effect of RBE, amount of NO was measured using the NO detection kit and the iNOS expression was measured by reverse transcriptase polymerase chain reaction (RT-PCR). And proinflammatory cytokines were measured by ELISA kit. As a result, the RBE reduced NO, iNOS expression and TNF-${\alpha}$, IL-$1{\beta}$, IL-6 production without cytotoxicity. Our results suggest that the RBE may have an anti-inflammatory property through suppressing inflammatory mediator productions and appears to be useful as an anti-inflammatory material.
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참고문헌 (33)
참고문헌 신청
Shin, H. G / 1997 / Development and Research Trends of Functional Food / Food Science and Industry, Korean Society of Food Science and Technology 30:2
배성문 / 2002 / 감마선 조사에 의한 왕겨, 미강, 맥강의 항산화능의 변화 / 한국식품영양과학회지 31(2):246~250
Qureshi, A. A. / 2000 / Isolation and identification of novel tocotrienols from rice bran with hypocholesterolemic, antioxidant and antitumor properties / J. Agric. Food Chem 48:3130
박은미 / 2006 / 쌀겨 추출물의 항암효과(in vitro) 및 항알레르기 효과 / 한국식품영양과학회지 35(10):1297~1303
Osawa, T. / 1985 / Antioxidative defense system in rice hull against damage caused by oxygen radicals / Agric. Biol. Chem 49:3085
배성문 / 2002 / 감마선 조사에 의한 왕겨, 미강, 맥강의 항산화능의 변화 / 한국식품영양과학회지 31(2):246~250
Qureshi, A. A. / 2000 / Isolation and identification of novel tocotrienols from rice bran with hypocholesterolemic, antioxidant and antitumor properties / J. Agric. Food Chem 48:3130
박은미 / 2006 / 쌀겨 추출물의 항암효과(in vitro) 및 항알레르기 효과 / 한국식품영양과학회지 35(10):1297~1303
Osawa, T. / 1985 / Antioxidative defense system in rice hull against damage caused by oxygen radicals / Agric. Biol. Chem 49:3085
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