지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.8
- 수록면
- 127 - 132 (6page)
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초록· 키워드
오류제보하기
Toll-like receptors (TLRs) play a fundamental role in innate immunity through their capacity to recognize pathogen-associated molecular patterns. Also, TLRs that are expressed in T cells are reported to function as co-stimulatory receptors. However, the functional capacity of TLRs on CD4 T and CD8 T cells has not been directly compared. Here we compared CD4 and CD8 T cell responses to TLR2 ligand plus TCR-mediated stimulation. Methods: TLR2 expression was analyzed on T cell subsets under naive and alloantigen-primed conditions. We analyzed the effects of TLR2 co-stimulation on proliferation and survival of T cell subsets in vitro when stimulated with soluble anti-CD3 in the presence or absence of synthetic ligand Pam<sub>3</sub>CSK<sub>4</sub>. Results: TLR2 expression on CD8 T cells was induced following activation; this expression was much higher than on CD4 T cells. Thus, the molecule was constitutively expressed on Listeriaspecific memory CD8 T cells. Based on these expression levels, proliferation and survival were markedly elevated in CD8 T cells in response to the TLR2 co-stimulation by Pam<sub>3</sub>CSK<sub>4</sub> compared with those in CD4 T cells. Conclusion: Our data show that TLR2 co-stimulation is more responsible for proliferation and survival of CD8 T cells than for that of CD4 T cells.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Takeda K / 2003 / Toll-like receptors / Annu Rev Immunol 21 : 335 ~ 376
2. [학술지(정기간행물)] - Medzhitov R / 2001 / Toll-like receptors and innate immunity / Nat Rev Immunol 1 : 135 ~ 145
3. [학술지(정기간행물)] - Komai-Koma M / 2004 / TLR2 is expressed on activated T cells as a costimulatory receptor / Proc Natl Acad Sci USA 101 : 3029 ~ 3034
4. [학술지(정기간행물)] - Gelman AE / 2004 / Toll-like receptor ligands directly promote activated CD4+ T cell survival / J Immunol 172 : 6065 ~ 6073
5. [학술지(정기간행물)] - Gelman AE / 2006 / The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation / Immunity 25 : 783 ~ 793
2. [학술지(정기간행물)] - Medzhitov R / 2001 / Toll-like receptors and innate immunity / Nat Rev Immunol 1 : 135 ~ 145
3. [학술지(정기간행물)] - Komai-Koma M / 2004 / TLR2 is expressed on activated T cells as a costimulatory receptor / Proc Natl Acad Sci USA 101 : 3029 ~ 3034
4. [학술지(정기간행물)] - Gelman AE / 2004 / Toll-like receptor ligands directly promote activated CD4+ T cell survival / J Immunol 172 : 6065 ~ 6073
5. [학술지(정기간행물)] - Gelman AE / 2006 / The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation / Immunity 25 : 783 ~ 793
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