지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Xanthohumol, a prenylated chalcone of the Hop plant (Humulus lupulus L.), has been reported to suppress tumor growth. 4-hydroxychalcone and isobavachalcone are chalcone derivatives and they have similar structure with xanthohumol. In the present study, we investigated the cytotoxic activities of chalcone and its derivatives, 4-hydroxychalcone, xanthohumol, and isobavachalcone, in MCF-7 and adriamycin resistant MCF-7 (MCF-7/ADR) breast cancer cells and HT-1080 fibrosarcoma cells. In a cell viability assay using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reagent, chalcone and 4-hydroxychalcone decreased cell viability in HT-1080 cells, but not in MCF-7 and MCF-7/ADR cells. Isobavachalcone showed similar cytotoxicity in HT-1080 cells, and only limited cytotoxicity in MCF-7 and MCF-7/ADR cells at very high concentration (50 ${\mu}M$). In contrast, xanthohumol showed concentration-dependent cytotoxicity in MCF-7, MCF-7/ADR, and HT-1080 cancer cells. Taken together, the structure-activity relationship of chalcone and its derivatives indicate that chalcones may be valuable cytotoxic compounds against selective cancer types.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protective Effects of Chalcone Derivatives for Acute Liver Injury in Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Anti-Invasive and Anti-Angiogenic Effects of Xanthohumol and Its Synthetic Derivatives
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
-
Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
The Role of the Hydrophobic Group on Ring A of Chalcones in the Inhibition of Interleukin-5
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Synthesis of New 2-Thiouracil-5-Sulphonamide Derivatives with Antibacterial and Antifungal Activity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
항염증효과를 갖는 2'-하이드록시찰콘 유도체의 합성
약학회지
2011 .01
-
담즙산 합성유도체(HS-1200)가 인체 유방암 세포주(MCF-7)에서 유도하는 방사선 감작 효과
Radiation oncology journal : ROJ
2004 .01
-
참옻 추출물의 MCF-7 인체 유방암 세포에서 증식 억제효과
대한한의학방제학회지
2016 .01
-
A New Cytotoxic Prenylated Chalcone from Sophora flavescens
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
知母 추출물이 MCF-7 세포의 생존율에 미치는 영향
대한한방내과학회지
2007 .01
-
Apoptotic Effects of 6-Gingerol in Human Breast Cancer Cells
International Journal of Oral Biology
2015 .01
-
Regulation of CYP1B1 Promotor Activity In MCF-7 Human Breast Cancer Cells
환경독성보건학회 심포지엄 및 학술대회
2005 .05
-
Comparison of in Vitro Cytotoxicity and Apoptogenic Activity of Magnesium Chloride and Cisplatin as Conventional Chemotherapeutic Agents in the MCF-7 Cell Line
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Evaluation of Cytotoxicity Effects of Chalcone Epoxide Analogues as a Selective COX-II Inhibitor in the Human Liver Carcinoma Cell Line
Journal of Pharmacopuncture
2017 .01
-
Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
강황(薑黃) 추출물이 유방암 세포주 MCF-7 증식 억제에 미치는 영향
대한본초학회지(본초분과학회지)
2006 .01
-
Regulation of the E-cadherin Expression on Human Breast Cancer Cell Line(MCF-7) by Anticancer Agents
한국실험동물학회 학술발표대회 논문집
1999 .05
-
Comparative Evaluation of Silibinin Effects on Cell Cycling and Apoptosis in Human Breast Cancer MCF-7 and T47D Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0