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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 13 - 20 (8page)
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초록· 키워드
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Objective: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker($RfC_{worker}$) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for PHMG-Phosphate(CAS No. 89697-78-9), It is a humidifier disinfectant that generated many lung injuries. Methods: We have investigated the recommendation or guidelines of foreign OEL for PHMG-Phosphate and the actual state of legal management in Korea. To examine the procedures and methods for recommendation OEL. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity $RfC_{worker}$ value was calculated for PHMG-Phosphate. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: The OEL for PHMG-Phosphate is recommended to be $0.01mg/m^3$. The recommended OEL is close to 10 times the RfCworker value of $0.000833mg/m^3$ calculated from the chemical dose-response hazard assessment, which is a 2017 study. The CMIT/MIT(3:1) mixture, which was a social issue as a humidifier disinfectant substance, was also exposed to the same ratio in March 2018, establish the OEL. It is recommended to establish OEL for PHMG-Phosphate to prevent worker health hazards and for chemical safety management.
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참고문헌 (20)
참고문헌 신청
ACGIH(American Conference of Governmental Industrial Hygienist) / 2018 / Threshold Limit Values(TLVs) for chemical and physical agents, and biological exposure indices / ACGIH
AIHA(American Industrial Hygiene Association). / 2011 / Workplace Environmental Exposure Levels(WEELs) values(2011)
Byeon SH / 2017 / Hazard and risk assessment and technical feasibility study of chemicals that are additionally established on Occupational Exposure Limits
DFG(German Research Foundation) / MAK collection for occupational health and safety
ECHA / CLP-harmonised classification and labelling(CLH)
AIHA(American Industrial Hygiene Association). / 2011 / Workplace Environmental Exposure Levels(WEELs) values(2011)
Byeon SH / 2017 / Hazard and risk assessment and technical feasibility study of chemicals that are additionally established on Occupational Exposure Limits
DFG(German Research Foundation) / MAK collection for occupational health and safety
ECHA / CLP-harmonised classification and labelling(CLH)
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Study of lung and liver damage mechanism of polyhexamethylene guanidine-phosphate (PHMG-P)
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Analysis of changes in asthma-related gene expression in rat lungs exposed to PHMG
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The mechanism of polyhexamethyleneguanidine-phosphate (PHMG-P) action in the induction of lung injury
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Promotion of pro-coagulant activity of red blood cells by PHMG-P exposure
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Effect of PHMG-P on TGF-β mediated signaling pathways in animal models
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PHMG-p에 의한 혈소판에서의 혈액응고 활성 촉진
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Effects of PHMG, a humidifier disinfectant, on eye-dryness using LC-MS-based metabolite profiling
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Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium
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2019 .06
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Effect of PHMG-p on TGF-β mediated signaling pathways in vivo and in vitro
환경독성보건학회 심포지엄 및 학술대회
2019 .04
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A mechanism of PHMG hepatotoxicity: ER stress-mediated apoptosis
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2021 .10
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¹H-NMR-based toxicometabolomics study of PHMG-p-induced pulmonary damage in mice
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Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats
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H-NMR based metabolomics study of PHMG-p-induced cytotoxicity in human alveolar epithelial A549 cells
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한국산업보건학회지
2018 .01
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PHMG (polyhexamethylene guanidine) 흡입독성참고치 산출을 통한 가습기살균제 노출등급 분류 및 특성
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