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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 195 - 207 (13page)
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Objectives: This study was performed to confirm whether plasma lead can be used as a chronic biomarker for the biological monitoring of exposure to lead. Methods: Lead concentrations in 66 plasma samples from retired lead workers (G.M. 60.25 years, Median 61.00 years) and 42 plasma samples from the general population (G.M. 53.76 years, Median 56.50 years) were measured using ICP/Mass. Tibia, whole blood, hemoglobin, hematocrit, and blood zinc protophorphyrin (ZPP) concentrations and urinary ${\delta}$-aminolevulinic acid (${\delta}-ALA$) were measured for correlation analysis with plasma lead. Results: The geometric mean concentration of lead in plasma was $0.23{\mu}g/L$ for the retired lead workers and $0.10{\mu}g/L$ for the general population sample. A simple correlation analysis of biomarkers showed that plasma lead concentration among the retired lead workers was highly correlated with lead concentration in the tibia and with blood lead concentration, and the plasma lead concentration among the general population correlated with ZPP concentration in the blood. The lead concentration in the tibia and the lead concentration in the whole blood increased with length of working period. As the period in the lead workplace increased, the ratio of lead in plasma to lead concentration in whole blood decreased. Conclusion: This study confirmed the possibility of a chronic biomarker of lead concentration in blood plasma as a biomarker. In the future, comparative studies with specific indicators will lead to more fruitful results.
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참고문헌 (31)
참고문헌 신청
American Conference of Governmental Industrial Hygienists / 2001 / Lead, elemental and inorganic / ACGIH lead BEI1-15
Fernando Barbosa / 2005 / A Critical Review of Biomarkers Used for Monitoring Human Exposure to Lead: Advantages, Limitations, and Future Needs / Environmental Health Perspectives 113(12):1669~1674
Behinaein S / 2017 / Age and sex influence on bone and blood lead concentrations in a cohort of the general population living in Toronto / Physiol Meas 38(3):431~451
Ingvar A. Bergdahl / 1999 / Lead in Plasma and Whole Blood from Lead-Exposed Children / Environ research section A 80(1):25~33
Ingvar A. Bergdahl / 2008 / Biomonitoring of Lead Exposure—Alternatives to Blood / Journal of Toxicology and Environmental Health, Part A 71(18):1235~1243
Fernando Barbosa / 2005 / A Critical Review of Biomarkers Used for Monitoring Human Exposure to Lead: Advantages, Limitations, and Future Needs / Environmental Health Perspectives 113(12):1669~1674
Behinaein S / 2017 / Age and sex influence on bone and blood lead concentrations in a cohort of the general population living in Toronto / Physiol Meas 38(3):431~451
Ingvar A. Bergdahl / 1999 / Lead in Plasma and Whole Blood from Lead-Exposed Children / Environ research section A 80(1):25~33
Ingvar A. Bergdahl / 2008 / Biomonitoring of Lead Exposure—Alternatives to Blood / Journal of Toxicology and Environmental Health, Part A 71(18):1235~1243
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