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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
김기영 (한양대학교 환경 및 산업의학연구소) 김종규 (안산대학교 산업보건센터) 윤기남 (안산대학교 산업보건센터) 박화미 (한양대학교 환경 및 산업의학연구소) 박훈희 (안산대학교 산업보건센터)
저널정보
한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제25권 제4호
발행연도
2015.1
수록면
493 - 505 (13page)

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Objectives: The purpose of this study was to evaluate the relevance of adjusting a urinary sample for urine hippuric correction value and its effects. Urinary biological monitoring data are typically adjusted to a constant creatinine and specific gravity concentration to correct for variable dilutions among spot samples. This study was conducted to evaluate the suitability of adjusting the urinary concentrations of urine creatinine and specific gravity(SG). Methods: We measured the concentrations of hippuric acid, in spot urine samples collected from control(119), case(120) individuals. The value of hippuric acid was adjusted by SG and urinary creatinine(HPLC & Jaffe). Results: The major results were as follows. The concentrations of urinary creatinine and SG for the control group were 1.84 g/L(SD 0.99) for arithmetic mean and 1.56 g/L(GSD 1.86) for geometric mean by HPLC method, 1.57 g/L (SD, 0.82) for arithmetic mean and 1.33 g/L(GSD 1.85) for geometric mean by Jaffe method, 1.028(SD 0.09) for arithmetic mean and 1.02(GSD 1.06) for geometric mean by refractometer. Hippuric acid levels were 0.40 g/L(SD 0.51) by arithmetic mean and 0.20 g/L(GSD 3.59). In that case the exposed group was 1.40 g/L(SD 0.58) for arithmetic mean and 1.28 g/L(GSD 1.55) for geometric mean by HPLC method, 1.27 g/L(SD 0.56) for arithmetic mean and 1.14 g/L(GSD 1.62) for geometric mean by Jaffe method, 1.045 L(SD 0.27) for arithmetic mean and 1.02(GSD 1.13) for geometric mean by refractometer(P<0.05). Hippuric acid levels were 0.67 g/L(SD 0.79) for arithmetic mean and 0.39 g/L(GSD 2.94)(p<0.05). The urine creatinine concentrations were affected by gender(p < 0.01) but SG levels were not affected by gender or age(p>0.05). After adjustment, urine hippuric acid was correlated with creatinine(HPLC & Jaffe)(r=0.723, P<0.05, r=0.708, P<0.05) and SG(r=0.936, P<0.05) and the control group shows significantly higher than the case group. In the case group for adjusted urine hippuric acid was correlated with creatinine(HPLC & Jaffe), (r=0.736, P<0.05), r=0.549, P<0.05), SG(r=0.549, P<0.05). After adjusting urine hippuric acid by urine creatinine(HPLC and Jaffe method) and specific gravity, significant associations were found between the control group and case group, respectively(r=0.832, P<0.05, r=0.845, P<0.05) and (r=0.841, P<0.05, r=0.849, P<0.05). Specific gravity adjustment appears to be more appropriate for variations in the urine creatinine method. Conclusion: we found that urinary creatinine concentrations were significantly affected by gender, and other factors and that care should therefore be exercised when correcting urinary metabolites according to the urinary creatinine concentration in spot urine. It is determined that additional study is needed for biological monitoring.
#adjustment urine #hippuric acid #Specific gravity #urinary creatinine

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참고문헌 (34)

참고문헌 신청
Barr DB / 2005 / Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements / Environ Health Perspect 113(2):192~200 google schola Baxmann AC / 2008 / Influence ofmuscle mass and physical activity on serum and urinary creatinine and serum cystatin C / Clin J AmSoc Nephrol 3(2):348~354 google schola Carrieri M / 2001 / Adjustment to concentration-dilution of spot urine samples: correlation between specific gravity and creatinine / Int Arch Occup Environ Health 74(1):63~67 google schola Chadha V / 2001 / Measurement of urinary concentration; a critical appraisal of methodologies / Pediatr Nephrol 16(4):374~382 google schola Chang SH / 1995 / A study on the Corrrelation of Ambient Toluene and Xylene with Biological Monitoring Index / The Kor, J. Occup. Med 7(2):295~305 google schola

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