폐글리세롤을 이용한 친환경 가소제의 경구투여독성 및 피부자극성 시험

강수정; 김희영; 박상원; 심은영; 김진환

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자료유형: 학술저널

저자정보: 강수정 (성균관대학교 고분자시스템공학과) 김희영 (성균관대학교 고분자시스템공학과) 박상원 (성균관대학교 고분자시스템공학과) 심은영 (성균관대학교 고분자시스템공학과) 김진환 (성균관대학교 고분자시스템공학과)

저널정보: 한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제25권 제3호

발행연도: 2015.1

수록면: 322 - 327 (6page)

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Objectives: The major objective of this study is the oral dose toxicity test and skin irritation test of eco-friendly plasticizer using crude glycerol derived from the biodiesel process. Methods: Glyceroldiacetate laurate(GDL) was synthesized from glycerol monolaurat(GML) and acetic acid. The synthesis of the GDL plasticizer was measured with nuclear magnetic resonance spectroscop(NMR) and FT-IR(Fourier Transform Infrared Spectrometer). To provide information on the safety of GDL, we carried out an oral dose toxicity test for GDL in Sprague-Dawley rats. Also, we carried out a skin irritation test for GDL in New Zealand White rabbits. Results: The oral dose toxicity test in Sprague-Dawley rats showed that GDL is a non-toxic material. The result of the skin irritation test on New Zealand White rabbits showed that GDL is non-irritating. Conclusions: From the results of oral dose toxicity test and skin irritation test, we concluded that the developed plasticizer showed excellent eco-friendly property. Based on our results, we confirmed the development of an eco-friendly non-phthalate plasticizer. Applicability for PVC toys and food and drug packaging materials was found.

#polyvinylchloride #PVC) #eco-friendly #plasticizer #oral dose toxicity test #skin irritation test

참고문헌 (17)

참고문헌 신청

Becker ME / 2010 / Toxic Chemicals in Toys and Children’s Products: Limitations of Current Responses and Recommendations for Government and Industry / Environ. Sci. Technol 44(21):7986~7991

Heudorf U / 2007 / Phthalates: Toxicology and exposure / Int. J. Hyg. Environ. Health 210(5):623~634

전선애 / 2008 / 바이오디젤 부산물인 폐글리세롤을 이용한 생물학적 1,3-propanediol 생산 / KSBB Journal 23(5):413~418

Kern RA / 1939 / Asthma and allergic rhinitis due to sensitization to phthalic anhydride, report of a case / J Allergy 10:164~165

김승환 / 2002 / 글리세롤을 함유한 유지산업 부산물의 1,3-propanediol 발효 / KSBB Journal 17(3):255~260

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