지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : Most of the mechanisms reported for antidepressant drugs are the enhancement of neurite outgrowth and neuronal survival in the rat hippocampus. Neural cell adhesion molecule 140(NCAM140) has been implicated as having a role in cell-cell adhesion, neurite outgrowth, and synaptic plasticity. In this report, we have performed to elucidate a correlation among chronic antidepressant treatments, NCAM140 expression, and activation of phosphorylated cyclicAMP responsive element binding protein(pCREB) which is a downstream molecule of NCAM140-mediated intracellular signaling pathway in the rat hippocampus. Methods : Fluoxetine(10mg/kg) was injected acutely(daily injection for 5days) or chronically(daily injection for 14days) in adult rats. RNA and protein were extracted from the rat hippocampus, respectively. Real-time RT-PCR was performed to analyze the expression pattern of NCAM140 gene and western blot analyses for the activation of the phosphorylation ratio of CREB. Results : Chronic fluoxetine treatments increased NCAM140 expression 1.3 times higher than control in rat hippocampus. pCREB immunoreactivity in the rat hippocampus with chronic fluoxetine treatment was increased 4.0 times higher than that of control. Conclusion : Chronic fluoxetine treatment increased NCAM140 expression and pCREB activity in the rat hippocampus. Our data suggest that NCAM140 and pCREB may play a role in the clinical efficacy of antidepressants promoting the neurite outgrowth and neuronal survival.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Fluoxetine Increases the Expression of NCAM140 and pCREB in Rat C6 Glioma Cells
PSYCHIATRY INVESTIGATION
2012 .01
-
침(鍼) 및 전침(電鍼)이 SHR 대뇌(大腦)에서 Doublecortin, PSA-NCAM, pCREB 양성 신경세포에 미치는 영향
대한침구의학회지
2004 .01
-
NCAM140 and pCREB Expression after Tianeptine Treatment of SH-SY5Y Cells
PSYCHIATRY INVESTIGATION
2014 .01
-
초음파가 흰쥐의 좌골신경 압좌손상 후 척수내 Neural Cell Adhesion Molecules의 발현에 미치는 영향
대한물리치료학회지(JKPT)
2007 .01
-
배양된 와우신경절에서 분화된 신경세포에서의신경접착분자와 Polysialic Acid의 발현
대한이비인후-두경부외과학회지
2007 .01
-
허쉬슈프렁병 환아의 무신경절 장관에서 Neural Cell Adhesion Molecule (NCAM) 과 Glial Cell Line-Derived Neurotrophic Factor (GDNF)의 발현
Journal of the Korean Association of Pediatric Surgeons : JKAPS
2001 .01
-
Fluoxetine Up-Regulates Bcl-xL Expression in Rat C6 Glioma Cells
PSYCHIATRY INVESTIGATION
2011 .01
-
[지상6]노화된 흰쥐 뇌에서 Doublecortin과 PSA-NCAM의 발현 변화
대한체질인류학회 학술대회 연제 초록
2003 .05
-
The Genetically Modified Polysialylated Form of Neural Cell Adhesion Molecule-Positive Cells for Potential Treatment of X-Linked Adrenoleukodystrophy
Yonsei Medical Journal
2013 .01
-
전침(電鍼)자극이 SHR 흰쥐의 Dentate Gyrus에서의 Doublecortin과 PSA-NCAM 양성 신경세포에 미치는 영향
대한침구의학회지
2003 .01
-
해마와 정신분열병
생물정신의학
2003 .01
-
Fluoxetine does Not Affect the Ischemia-Induced Increase of Neurogenesis in the Adult Rat Dentate Gyrus
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Effects of Non-saponin Red Ginseng Components on the Function of Brain Cells
Journal of Ginseng Research
2008 .03
-
Role of Neuropeptide Y and Proopiomelanocortin in Fluoxetine- Induced Anorexia
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Fluoxetine의 개관
생물치료정신의학
1995 .06
-
선택적 함구증 환자에서의 Fluoxetine 치험
소아청소년정신의학
1997 .12
-
Population Pharmacokinetics of Fluoxetine
대한약학회 학술대회
2001 .01
-
주요우울증에서 Fluoxetine과 Amitriptyline의 치료효과에 대한 이중맹검법 비교연구
정신신체의학
1995 .01
-
뇌졸중 후 우울증 환자에서 플루옥세틴에 의해 유발된 조증 1례 -증례보고-
Annals of Rehabilitation Medicine
2008 .01
-
[지상11]Comparative study on the expression of c-fos and pCREB in the rat brain after the treatment of MK801 or 7-nitroindazole.
대한체질인류학회 학술대회 연제 초록
2004 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0