지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives Restless legs syndrome (RLS) is a sleep disorder characterized by uncomfortable and unpleasant sensations in the legs and an urge to move the legs, usually at night. The aim of this study is to investigate the incidence of RLS in patients with late life depression and its influence on various clinical outcomes such as severity of depression, sleep quality, cognitive function, and quality of life and accordingly, to elucidate the clinical significance of RLS in patients with late life depression (LLD). Methods This study enlisted 170 depressive patients aged 65 years or older from an outpatient clinic. Structured diagnostic interviews were performed using the Korean version of the Mini-International Neuropsychiatric Interview. All patients completed the questionnaires, including the International RLS Severity Scale, the Korean version of Short-Form 36-Item Health Survey (SF-36), and the Pittsburgh Sleep Quality Index (PSQI). The severity of depression was evaluated by the Korean form of the Geriatric Depression Scale (KGDS) and the level of global cognition was assessed by the Mini-Mental State Examination in the Korean version of The Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (MMSE-KC). Results The incidence of RLS was 17.6% in LLD patients. RLS was more prevalent among the subjects with major depressive disorder (MDD) than those with minor depressive disorder or subsyndromal depressive disorder. The RLS group showed higher score in the KGDS than the Non-RLS group but the difference did not reach the statistical significance (p = 0.095, Student t-test). The mean PSQI score was significantly higher in the RLS group than in the Non-RLS group (p = 0.001, Student t-test). The MMSE-KC score was also lower in the RLS group than in Non-RLS group (p = 0.009, analysis of covariance). But, there was no difference in the score of SF-36 between the RLS group and the Non-RLS group. Conclusions RLS is common in LLD patients, especially in the patients with MDD and is associated with poor sleep quality and cognitive dysfunction, indicating that RLS is clinically significant in patients with LLD. Therefore, RLS should be considered as an important clinical issue in the management of LLD.
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참고문헌 (30)
참고문헌 신청
Ekbom KA / 1965 / Restless legs / Lakartidningen 62:2376~2382
Abetz L / 2004 / Evaluating the quality of life of patients with restless legs syndrome / Clin Ther 26:925~935
Cho YW / 2012 / Assessing health-related quality of life in patients with restless legs syndrome in Korea : comparison with other chronic medical diseases / Sleep Med 13:1158~1163
이도윤 / 2011 / 일 대학병원 정신과 외래를 방문한 우울증 환자에서의 하지불안증후군 / 생물치료정신의학 17(1):38~46
Kim KW / 2010 / Prevalence, comorbidities and risk factors of restless legs syndrome in the Korean elderly population - results from the Korean Longitudinal Study on Health and Aging / J Sleep Res 19(1 Pt 1):87~92
Abetz L / 2004 / Evaluating the quality of life of patients with restless legs syndrome / Clin Ther 26:925~935
Cho YW / 2012 / Assessing health-related quality of life in patients with restless legs syndrome in Korea : comparison with other chronic medical diseases / Sleep Med 13:1158~1163
이도윤 / 2011 / 일 대학병원 정신과 외래를 방문한 우울증 환자에서의 하지불안증후군 / 생물치료정신의학 17(1):38~46
Kim KW / 2010 / Prevalence, comorbidities and risk factors of restless legs syndrome in the Korean elderly population - results from the Korean Longitudinal Study on Health and Aging / J Sleep Res 19(1 Pt 1):87~92
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