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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 1,409 - 1,415 (7page)
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Obesity is especially a serious health problem in industrialized countries, because it is considered to be a risk factor associated with the genesis or development of various metabolic diseases, including cardiovascular disease and type 2 diabetes mellitus. The purpose of this study was to investigate the effects of tanshinone IIA from Salvia miltiorrhiza Bunge on induction of apoptossis and inhibition of adipogenesis in in 3T3-L1 preadipocytes and adipocytes. The results demonstrated that tanshinone IIA decreased cell population growth of 3T3-L1 preadipocytes, assessed with the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and LDH (lactate dehydrogenase) assay. Flow cytometric analysis of 3T3-L1 preadipocytes exposed to tanshinone IIA showed that apoptotic cells increased in a timeand dose-dependent manner. Treatment with tanshinone IIA decreased the number of normal cells and increased the number of apoptotic cells in a dose-dependent manner. The induction of apoptosis in 3T3-L1 preadipocytes by tanshinone IIA was mediated through the activation of caspase-3 and Bax, and then through the cleavage of PARP and the down-regulation of Bcl-2. Moreover, tanshinone IIA significantly decreased the amount of intracellular triglycerides and GPDH (glycerol-3-phosphate dehydrogenase) activity in 3T3-L1 adipocytes. Our results suggest that tanshinone IIA efficiently induces apoptosis and inhibits adipogenesis in 3T3-L1 preadipocytes and adipocytes.
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단삼 유래 Tanshinone IIA가 3T3-L1 세포의 아포토시스 유도와 지방형성 억제에 미치는 영향
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Effects of Tanshinone IIA on the Hepatotoxicity and Gene Expression Involved in Alcoholic Liver Disease
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
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Salvia Miltiorrhiza-induced Regulation of Osteoclastogenesis and the Determination of Components-Tanshinone I, Tanshinone IIA, Cryptotanshinone and Dihydrotanshinone using LC-MS/MS
대한임상약리학회 학술대회
2006 .01
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Molecular Mechanisms of Inhibitory Activities of Tanshinones on Lipopolysaccharide-Induced Nitric Oxide Generation in RAW 264.7 Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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Inhibition of Osteoclast Differentiation by Tanshinones from the Root of Salvia miltiorrhiza Bunge
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Inhibition of Nitric Oxide and TNF-(equation omitted) production in microglia cell by tanshinones
대한약학회 학술대회
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A Potential Target of Tanshinone IIA for Acute Promyelocytic Leukemia Revealed by Inverse Docking and Drug Repurposing
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Effects of Tanshinone I Isolated from Salvia miltiorrhiza Bunge on Arachidonic Acid Metabolism and In Vivo Inflammatory Responses
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Locoregional Spread and Survival of Stage IIA1 versus Stage IIA2 Cervical Cancer
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Inhibitory Activity of Diacylglycerol Acyltransferase by Tanshinones from the Root of Salvia miltiorrhiza
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Tanshinone 단삼성분의 전신성 캔디다증에 대한 항균효과
약학회지
2013 .01
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Tanshinone I treatment protect against ischemic neuronal damage induced by transient cerebral ischemia via appropriate balance maintenance between pro-oxidants and antioxidants
한국실험동물학회 학술발표대회 논문집
2013 .02
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Tanshinone IIA Reverses the Malignant Phenotype of SGC7901 Gastric Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Tanshinones from Salvia miltiorrhiza inhibits mast cell degranulation by blocking the tyrosine phosphyorylation of MAPK
대한약학회 학술대회
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Investigation of the Improved Effects of $2-Hydroxypropyl-{\beta}-Cyclodextrin$ on Solubility, Dissolution Rate, and Intestinal Absorptive Profile of Tanshinone IIA in Rats
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2007 .01
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Anti-inflamatory Effect of Tanshinone I in Neuroprotection Against Cerebral Ischemia-reperfusion Injury in the Gerbil Hippocampus
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