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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제28권 제8호
- 발행연도
- 2005.1
- 수록면
- 909 - 913 (5page)
이용수
초록· 키워드
오류제보하기
We screened natural products to find compounds with anti-osteoporotic potential using a coculture-based system by which osteoclast differentiation is effectively achieved. We found that methylene chloride soluble fraction of the root of Salvia miltiorrhiza Bunge (Labiatae) suppressed osteoclast differentiation. Five tanshinones, tanshinone IIA (1), tanshinone I (2), cryptotanshinone (3), 15,16-dihydrotanshinone I (4), and ferruginol (5) were subsequently isolated from fraction. Among the five compounds, compounds 1-4 reduced the formation of TRAPpositive multinuclear osteoclasts. These results suggest that the identified tanshinones may be useful candidates for development of therapeutic agents to treat osteoporosis and other bone-resorptive diseases.
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Salvia Miltiorrhiza-induced Regulation of Osteoclastogenesis and the Determination of Components-Tanshinone I, Tanshinone IIA, Cryptotanshinone and Dihydrotanshinone using LC-MS/MS
대한임상약리학회 학술대회
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단삼 유래 Tanshinone IIA가 3T3-L1 세포의 아포토시스 유도와 지방형성 억제에 미치는 영향
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2009 .12
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Effects of Tanshinone I Isolated from Salvia miltiorrhiza Bunge on Arachidonic Acid Metabolism and In Vivo Inflammatory Responses
대한약학회 학술대회
2000 .01
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Inhibitory Activity of Diacylglycerol Acyltransferase by Tanshinones from the Root of Salvia miltiorrhiza
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
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Molecular Mechanisms of Inhibitory Activities of Tanshinones on Lipopolysaccharide-Induced Nitric Oxide Generation in RAW 264.7 Cells
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2004 .01
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Effects of Tanshinone IIA on the Hepatotoxicity and Gene Expression Involved in Alcoholic Liver Disease
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2008 .01
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단삼 유래 Tanshinone IIA가 3T3-L1 세포의 아포토시스 유도와 지방형성 억제에 미치는 영향
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Tanshinones from Salvia miltiorrhiza inhibits mast cell degranulation by blocking the tyrosine phosphyorylation of MAPK
대한약학회 학술대회
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Inhibition of Prostaglandin and Nitric Oxide Production in Lipopolysaccharide-treated RAW 264.7 Cells by Tanshinones from the Roots of Salvia miltiorrhiza Bunge
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Inhibition of Nitric Oxide and TNF-(equation omitted) production in microglia cell by tanshinones
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Effect of TGF-β1 on Osteoclast Differentiation
International Journal of Oral Biology
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Anti-osteoporotic effect of Salvia miltiorrhiza extracts
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2003 .10
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The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1999 .01
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Tanshinone I treatment protect against ischemic neuronal damage induced by transient cerebral ischemia via appropriate balance maintenance between pro-oxidants and antioxidants
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