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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제6호
- 발행연도
- 2007.1
- 수록면
- 755 - 760 (6page)
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초록· 키워드
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Clerodendron trichotomum Tunberg Leaves (CTL) have been used for centuries in Chinese folk medicine for their anti-inflammatory properties. To investigate the molecular mechanism of anti-inflammation by CTL, we analyzed the regulation of TNF-${\alpha}$ expression in RAW 264.7 Cell a key step in inflammation. The effect of CTL on the production and expression of tumornecrosis factor-${\alpha}$ (TNF-${\alpha}$) was determined by enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR). CTL inhibited the production and expression of TNF-${\alpha}$ in LPS-stimulated RAW 264.7 cells in a dose-dependent manner. In addition activation of NF-${\kappa}$B, which controls TNF-${\alpha}$ expression, was inhibited in LPS-stimulated RAW 264.7 cells by CTL in a dose-dependent manner, as demonstrated by an electrophoretic mobility shift assay (EMSA). Furthermore, CTL inhibited activation of NF-${\kappa}$B through inhibition of I${\kappa}$B degradation, as demonstrated by an western blot analysis of I${\kappa}$B-${\alpha}$. These results suggest that CTL inhibits the expression of the pro-inflammation gene through the inhibition of NF-${\kappa}$B dependent pathway in RAW 264.7 cells.
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