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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 67 - 74 (8page)
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Objectives : TheHaedokgumhwa-sanwater extract (HDKHS) is used in Korea, Japan and China as a traditional therapeutic agent to cure an infectious disease. But its study is not enough. Therefore, the present study focused on the elucidation of HDKHS to investigate the anti-inflammatory effects and to established the possible mechanisms involved in its action on LPS-stimulated immune response in murine macrophages.Methods : Inflammatory status was induced by LPS and measured by increasement of inflammatory mediators. LPS induced secretions of NO and PGE<sub>2</sub>in RAW 264.7 cells were measured using griess reagent and enzyme-linked immunosorbent assay (ELISA) kit respectively. production of IL-6 was examined using ELISA kit and expression of IL-6 mRNA was measured by RT-PCR method. To investigate the effects of HDKHS on inflammatory mediators, such as iNOS, COX-2 and MAPKs, western blot and RT-PCR were performed.Results : HDKHS significantly reduced production of NO and PGE2 which were induced by LPS. Also, activation of IL-6 was reduced both protein and mRNA levels. The expressions of inflammatory mediator include iNOS and COX-2 were decreased by pretreatment with HDKHS. futhermore The result showed HDKHS down-regulate the LPS induced phosphorylation of ERK 1/2, one of the MAPK family, which is considered as a main regulator of transmission from pathogens to nucleus of immune cells.Conclusions : Our results suggest that the anti-inflammatory properties of HDKHS may stem from the inhibition of pro-inflammatory mediators via suppression of initiation of inflammatory response by inhibiting MAPKs signaling pathways.
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참고문헌 (28)
참고문헌 신청
Wang HT / 2015 / Expression changes of inflammatory factors in the rat lung of decompression sickness induced by fast buoyancy ascent escape / Undersea Hyperb Med 42(1):15~22
Lomba KS / 2015 / Use of minimally invasive gingival biopsies in the study of inflammatory mediators expression and their correlation with gingival fluid in patients with chronic periodontitis / Indian J Dent Res 26(2):126~130
Bae BC / Commentary on Nei-Jing / Sungbosa :725~728
Donguihak Dictionary Compilation Committee / 2003 / New donguihak Dictionary / Yeo Gangchulpansa :218
Mum RM / 1991 / Documentary Consideration about Stress / J Orient Neuropsychiatry 2(1):38~50
Lomba KS / 2015 / Use of minimally invasive gingival biopsies in the study of inflammatory mediators expression and their correlation with gingival fluid in patients with chronic periodontitis / Indian J Dent Res 26(2):126~130
Bae BC / Commentary on Nei-Jing / Sungbosa :725~728
Donguihak Dictionary Compilation Committee / 2003 / New donguihak Dictionary / Yeo Gangchulpansa :218
Mum RM / 1991 / Documentary Consideration about Stress / J Orient Neuropsychiatry 2(1):38~50
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