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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objectives : The purpose of this study was to investigate inhibitory effects of steamed Polygonatum odoratum extract (POE) on insulin resistance in rat skeletal muscle cells, L6 cells.Methods : Polygonatum odoratum (P. odoratum) extract was extracted with ethyl acetate. Activity of α-glucosidase in POE was measured for blood glucose regulation. MTT assay was examined for cell toxicity. Western blot analysis for measurement of adiponectine, peroxisome proliferator-activated receptorγ (PPARγ), insulin receptor substrate (IRS), glucose transporter 4 (Glut-4) and phosphorylation of serine/threonine-specific protein kinase (Akt) expressions were performed. Akt signaling pathway were analyzed with LY294002, which is a specific PI3K/Akt inhibitor.Results : The results revealed that POE inhibited α-glucosidase activity. Treatment of POE in L6 cells inhibited the differentiation of L6 cells compared to those of vehicl control. Additionally, protein expressions of adiponectine, PPARγ, IRS and Glut-4 were significantly regulated compared to those of vehicle control (p < 0.05), respectively. Futhermore, phosphorylation of Akt was increased in L6 cells treated with POE compared to that of vehicle control (p < 0.05). pAkt expression was significantly accentuated with Akt inhibitor (LY294002).Conclusions : These results suggest that POE may have potential as a natural agent for prevention/improvement of diabetes, especially, regulation of blood glucose. Therefore, further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of these.
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참고문헌 (25)
참고문헌 신청
Korean Society For The Study of Obestity Fact Sheet
World Health Organization (WHO) / 2011 / Obesity and overweight in Media centre
Koplman PG / 2000 / Obesity as a medical problem / Nature 404(6778):635~643
Korean Diabetes Association / Diabetes factsheet 2013
Lee CB / Daehan plant handbook / Hyangmoonsa :213~214
World Health Organization (WHO) / 2011 / Obesity and overweight in Media centre
Koplman PG / 2000 / Obesity as a medical problem / Nature 404(6778):635~643
Korean Diabetes Association / Diabetes factsheet 2013
Lee CB / Daehan plant handbook / Hyangmoonsa :213~214
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