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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 90 - 94 (5page)
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초록· 키워드
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The potential health risk from inhalational exposure of diesel exhaust particulates (DEP) has gained considerable scientific interests. However, the long-term in vivo behavior of DEP have not been clearly understood due to the difficulty of accurate analysis of these substances in a living subject. We herein demonstrate a detail protocol for the preparation of radiolabeled DEP using a radioactive-iodine-tagged pyrene analog. The purified $^{125}I$-labeled pyrene ($[^{125}I]1$) was obtained with a good radiochemical yield ($32{\pm}4%$, n=3) and high radiochemical purity (>99%) from the stannylated precursor 2. Next, the purified $[^{125}I]1$ was successfully assembled into the DEP suspension in an efficient manner. The radiolabeled DEP was highly stable in a mouse serum for 7 days without significant deiodination or dissociation of $[^{125}I]1$. These results clearly indicate that the present radiolabeling method will be useful for biodistribution study of carbonaceous particulates in vivo.
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참고문헌 (11)
참고문헌 신청
Wadas TJ / 2010 / Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease / Chem Rev 110:2858~2902
Holland JP / 2010 / 89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo / J Nucl Med 51:1293~1300
Holland JP / 2009 / Standardized methods for the production of high specific-activity zirconium-89 / Nucl Med Biol 36:729~739
Pandya DN / 2017 / Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development / Chem Sci 8:2309~2314
Pandit-Taskar N / 2014 / 89Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer / Eur J Nucl Med Mol Imaging 41:2093~2105
Holland JP / 2010 / 89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo / J Nucl Med 51:1293~1300
Holland JP / 2009 / Standardized methods for the production of high specific-activity zirconium-89 / Nucl Med Biol 36:729~739
Pandya DN / 2017 / Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development / Chem Sci 8:2309~2314
Pandit-Taskar N / 2014 / 89Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer / Eur J Nucl Med Mol Imaging 41:2093~2105
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