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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 61 - 68 (8page)
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Purine type compounds has been recently reported to cause the death for lung cancer cell, related to microtubules-targeting agents (MTAs). Therefore it can be used to develop as theranostic radiopharmceuticals in nuclear medicine or gadolinium-based MRI imaging agents by chelate chemistry. In the study, we tried to chemically bind a DOTA chelate on the end of purine compound and obtained a specific conjugate of DOTA-purine for metal coordination. In particular, radiometal like Cu-64, for the development of MRI imaging agents, can be utilized to choice good candidates before the synthesis of gadolinium complexes. By the screening of radioisotope technique, Gd-DOTA-purine type complex was successfully prepared and showed MRI imaging for lung cancer cell into the mouse model.
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참고문헌 (10)
참고문헌 신청
2018 / 국가암등록 통계사업 / 보건복지부
Lopez-Ayllon BD / 2014 / Cancer stem cells and cisplatinresistant cells isolated from non-small-lung cancer cell lines constitute related cell populations / Caner Med 3:1099~1111
Kuo TC / 2016 / Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin / J Med Chem 59:8521~8534
Wahsner J / 2019 / Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers / Chem Rev 119:957~1057
Yohan Jeong / 2018 / Theranostics and contrast agents for magnetic resonance imaging / 생체재료학회지 22(3):159~171
Lopez-Ayllon BD / 2014 / Cancer stem cells and cisplatinresistant cells isolated from non-small-lung cancer cell lines constitute related cell populations / Caner Med 3:1099~1111
Kuo TC / 2016 / Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin / J Med Chem 59:8521~8534
Wahsner J / 2019 / Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers / Chem Rev 119:957~1057
Yohan Jeong / 2018 / Theranostics and contrast agents for magnetic resonance imaging / 생체재료학회지 22(3):159~171
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