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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 132 - 136 (5page)
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Studies of cancer heterogeneity have received considerable attention recently, because the presence or absence of resistant sub-clones may determine whether or not certain therapeutic treatments are effective. Previously, we have reported G64, a co-regulated gene module composed of 64 different genes, can differentiate tumor intra- or inter-subpopulations in lung adenocarcinomas (LADCs). Here, we investigated whether the G64 module genes were also expressed distinctively in different subpopulations of other cancers. RNA sequencing-based transcriptome data derived from 22 cancers, except LADC, were downloaded from The Cancer Genome Atlas (TCGA). Interestingly, the 22 cancers also expressed the G64 genes in a correlated manner, as observed previously in an LADC study. Considering that gene expression levels were continuous among different tumor samples, tumor subpopulations were investigated using extreme expressional ranges of G64-i.e., tumor subpopulation with the lowest 15% of G64 expression, tumor subpopulation with the highest 15% of G64 expression, and tumor subpopulation with intermediate expression. In each of the 22 cancers, we examined whether patient survival was different among the three different subgroups and found that G64 could differentiate tumor subpopulations in six other cancers, including sarcoma, kidney, brain, liver, and esophageal cancers.
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참고문헌 (22)
참고문헌 신청
Bedard PL. / 2013 / Tumour heterogeneity in the clinic / Nature 501:355~364
Cusnir M. / 2012 / Inter-tumor heterogeneity / Hum Vaccin Immunother 8:1143~1145
Lyng H. / 2001 / Intra-and intertumor heterogeneity in blood perfusion of human cervical cancer before treatment and after radiotherapy / Int J Cancer 96:182~190
Jiang YH. / 2013 / Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing / Am J Hum Genet 93:249~263
Pinto N. / 2011 / Clinically relevant genetic variations in drug metabolizing enzymes / Curr Drug Metab 12:487~497
Cusnir M. / 2012 / Inter-tumor heterogeneity / Hum Vaccin Immunother 8:1143~1145
Lyng H. / 2001 / Intra-and intertumor heterogeneity in blood perfusion of human cervical cancer before treatment and after radiotherapy / Int J Cancer 96:182~190
Jiang YH. / 2013 / Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing / Am J Hum Genet 93:249~263
Pinto N. / 2011 / Clinically relevant genetic variations in drug metabolizing enzymes / Curr Drug Metab 12:487~497
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