지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 353 - 362 (10page)
- DOI
- 10.15324/kjcls.2021.53.4.353
이용수
초록· 키워드
오류제보하기
Cancer is a global health problem. There are diverse types of cancers, but there are several common pathways which lead to the development of cancer. Changes in gene expression might be the most common similarity found in almost all cancers. An understanding of the underlying changes in gene expression during cancer progression could lay a valuable foundation for the development of cancer therapeutics and even cancer vaccines. In this study, a well-known carcinogen, N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), was employed to induce changes in gene expression in normal stomach cells. MNNG is known to cause cancer by inducing damage to DNA in MNNG-treated mammalian cells and animals fed with this carcinogen. An analysis was performed by comparing the differentially expressed genes (DEGs) caused by MNNG treatment with DEGs in stomach cancer cell lines. To this end, methods of analysis for functional categorization and protein-protein interaction networks, such as gene ontology (GO), the database for annotation, visualization, and integrated discovery (DAVID), Kyoto encyclopedia of genes and genomics (KEGG) and search tool for the retrieval of interacting genes/proteins (STRING), were used. As a result of these analyses, MNNG-regulated specific genes and interaction networks of their protein products that contributed to stomach cancer were identified.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
홍세리 / 2021 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2018 / Cancer Research and Treatment 53(2):301~315
Sugimura T / 1967 / Tumour production in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine / Nature 216:943~944
Lin L / 2019 / Chronic CagA-positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell-like properties in gastric mucosal epithelial cells / J Cell Biochem 120:17635~17649
Kobori O / 1984 / Biochemical study of the position specificity of rat gastrointestinal cancer induced by MNNG / Nihon Shokakibyo Gakkai Zasshi 81:277
Hamidreza Miri / 2011 / A Noninvasive Method for Early Detection of MNNG-Induced Gastric Cancer of Male Wistar rat: Ultrasonic Study / Ultrasound in Medicine & Biology 37(5):780~787
Sugimura T / 1967 / Tumour production in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine / Nature 216:943~944
Lin L / 2019 / Chronic CagA-positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell-like properties in gastric mucosal epithelial cells / J Cell Biochem 120:17635~17649
Kobori O / 1984 / Biochemical study of the position specificity of rat gastrointestinal cancer induced by MNNG / Nihon Shokakibyo Gakkai Zasshi 81:277
Hamidreza Miri / 2011 / A Noninvasive Method for Early Detection of MNNG-Induced Gastric Cancer of Male Wistar rat: Ultrasonic Study / Ultrasound in Medicine & Biology 37(5):780~787
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