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학술저널
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Fernando, Pattage Madushan Dilhara Jayatissa (Department of Biochemistry, School of Medicine, Jeju National University) Piao, Mei Jing (Department of Biochemistry, School of Medicine, Jeju National University) Kang, Kyoung Ah (Department of Biochemistry, School of Medicine, Jeju National University) Ryu, Yea Seong (Department of Biochemistry, School of Medicine, Jeju National University) Hewage, Susara Ruwan Kumara Madduma (Department of Biochemistry, School of Medicine, Jeju National University) Chae, Sung Wook (Aging Research Center, Korea Institute of Oriental Medicine) Hyun, Jin Won (Department of Biochemistry, School of Medicine, Jeju National University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제24권 제1호
발행연도
2016.1
수록면
75 - 84 (10page)

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This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. RA also attenuated UVB-induced oxidative macromolecular damage, including protein carbonyl content, DNA strand breaks, and the level of 8-isoprostane. Furthermore, RA increased the expression and activity of superoxide dismutase, catalase, heme oxygenase-1, and their transcription factor Nrf2, which are decreased by UVB radiation. Collectively, these data indicate that RA can provide substantial cytoprotection against the adverse effects of UVB radiation by modulating cellular antioxidant systems, and has potential to be developed as a medical agent for ROS-induced skin diseases.

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