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논문 기본 정보

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학술저널
저자정보
Han, Xia (School of Medicine, Jeju National University) Piao, Mei Jing (School of Medicine, Jeju National University) Kim, Ki Cheon (School of Medicine, Jeju National University) Hewage, Susara Ruwan Kumara Madduma (School of Medicine, Jeju National University) Yoo, Eun Sook (School of Medicine, Jeju National University) Koh, Young Sang (School of Medicine, Jeju National University) Kang, Hee Kyoung (School of Medicine, Jeju National University) Shin, Jennifer H (Department of Mechanical Engineering & Graduate School of Medical Science and Engineering, KAIST) Park, Yeunsoo (National Fusion Research Institute, Plasma Technology Research Center) Yoo, Suk Jae (National Fusion Research Institute, Plasma Technology Research Center) Chae, Sungwook (Aging Research Center, Korea Institute of Oriental Medicine) Hyun, Jin Won (School of Medicine, Jeju National University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제23권 제4호
발행연도
2015.1
수록면
357 - 366 (10page)

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Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced intracellular reactive oxygen species (ROS) and attenuated the oxidative modification of DNA, lipids, and proteins in response to UVB radiation. Moreover, isorhamnetin repressed UVB-facilitated programmed cell death in the keratinocytes, as evidenced by a reduction in apoptotic body formation, and nuclear fragmentation. Additionally, isorhamnetin suppressed the ability of UVB light to trigger mitochondrial dysfunction. Taken together, these results indicate that isorhamnetin has the potential to protect human keratinocytes against UVB-induced cell damage and death.

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