지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 371 - 379 (9page)
이용수
초록· 키워드
오류제보하기
Store-operated calcium entry (SOCE), a major mode of extracellular calcium entry, plays roles in a variety of cell activities. Accumulating evidence indicates that the intracellular calcium ion concentration and calcium signaling are critical for the responses induced by oxidative stress. The present study was designed to investigate the potential effect of SOCE inhibition on $H_2O_2$-induced apoptosis in endothelial progenitor cells (EPCs), which are the predominant cells involved in endothelial repair. The results showed that $H_2O_2$-induced EPC apoptosis was reversed by SOCE inhibition induced either using the SOCE antagonist ML-9 or via silencing of stromal interaction molecule 1 (STIM1), a component of SOCE. Furthermore, SOCE inhibition repressed the increases in intracellular reactive oxygen species (ROS) levels and endoplasmic reticulum (ER) stress and ameliorated the mitochondrial dysfunction caused by $H_2O_2$. Our findings provide evidence that SOCE inhibition exerts a protective effect on EPCs in response to oxidative stress induced by $H_2O_2$ and may serve as a potential therapeutic strategy against vascular endothelial injury.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Increased store-operated Ca2+ entry mediated by GNB5 and STIM1
The Korean Journal of Physiology & Pharmacology
2018 .05
-
Store-operated calcium entry in the satellite glial cells of rat sympathetic ganglia
The Korean Journal of Physiology & Pharmacology
2024 .01
-
SKF96365 impedes spinal glutamatergic transmission-mediated neuropathic allodynia
The Korean Journal of Physiology & Pharmacology
2023 .01
-
Circulating Vascular Progenitor Cells in Moyamoya Disease
대한신경외과학회지
2015 .01
-
Effects of Bevacizumab on Bcl-2 Expression and Apoptosis in Retinal Pigment Epithelial Cells under Oxidative Stress
Korean Journal of Ophthalmology
2015 .01
-
Galpha12 Protects Vascular Endothelial Cells from Serum Withdrawal-Induced Apoptosis through Regulation of miR-155
Yonsei Medical Journal
2016 .01
-
Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated Ca2+ Entry Pathway
Allergy, Asthma & Immunology Research
2023 .05
-
Regulatory mechanisms of the store-operated Ca2+ entry through Orai1 and STIM1 by an adaptor protein in non-excitable cells
International Journal of Oral Biology
2022 .09
-
Tea Flavonoids Induced Differentiation of Peripheral Blood-derived Mononuclear Cells into Peripheral Blood-derived Endothelial Progenitor Cells and Suppressed Intracellular Reactive Oxygen Species Level of Peripheral Blood-derived Endothelial Progenitor C
Natural Product Sciences
2016 .06
-
Protective role of β-carotene in heat-induced apoptosis and oxidative stress in mice testes
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Propofol protects against oxidative-stress-induced COS-7 cell apoptosis by inducing autophagy
Journal of dental anesthesia and pain medicine
2017 .01
-
Effects on apoptosis and oxidative stress of cigarette smoke extract in mouse embryonic stem cells
한국실험동물학회 학술발표대회 논문집
2019 .01
-
The role of ginsenoside Rb1, a potential natural glutathione reductase agonist, in preventing oxidative stress-induced apoptosis of H9C2 cells
Journal of Ginseng Research
2020 .03
-
High Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Orai1 Expression Is Closely Related with Favorable Prognostic Factors in Clear Cell Renal Cell Carcinoma
Journal of Korean Medical Science
2016 .01
-
Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
The Korean Journal of Physiology & Pharmacology
2020 .01
-
Protective effects of remifentanil against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress in human osteoblasts
Journal of dental anesthesia and pain medicine
2016 .01
-
Betaine Effects on Morphology, Proliferation, and p53-induced Apoptosis of HeLa Cervical Carcinoma Cells in Vitro
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Oxidative Stress-Induced Apoptosis in Chronic Myelogenous Leukemia K562 Cells by an Active Compound from the Dithio-Carbamate Family
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0