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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 14 (14page)
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초록· 키워드
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Resveratrol was first isolated in 1939 by Takaoka from Veratrum grandiflorum O. Loes. Following this discovery, sporadic descriptive reports appeared in the literature. However, spurred by our seminal paper published nearly 60 years later, resveratrol became a household word and the subject of extensive investigation. Now, in addition to appearing in over 20,000 research papers, resveratrol has inspired monographs, conferences, symposia, patents, chemical derivatives, etc. In addition, dietary supplements are marketed under various tradenames. Once resveratrol was brought to the limelight, early research tended to focus on pharmacological activities related to the cardiovascular system, inflammation, and cancer but, over the years, the horizon greatly expanded. Around 130 human clinical trials have been (or are being) conducted with varying results. This may be due to factors such as disparate doses (ca. 5 to 5,000 mg/day) and variable experimental settings. Further, molecular targets are numerous and a dominant mechanism is elusive or nonexistent. In this context, the compound is overtly promiscuous. Nonetheless, since the safety profile is pristine, and use as a dietary supplement is prevalent, these features are not viewed as detrimental. Given the ongoing history of resveratrol, it is reasonable to advocate for additional development and further clinical investigation. Topical preparations seem especially promising, as do conditions that can respond to anti-inflammatory action and/or direct exposure, such as colon cancer prevention. Although the ultimate fate of resveratrol remains an open question, thus far, the compound has inspired innovative scientific concepts and enhanced public awareness of preventative health care.
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참고문헌 (122)
참고문헌 신청
Afaq F / 2003 / Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice, Toxicol / Appl. Pharmacol 186:28~37
Aggarwal BB / 2006 / Resveratrol in Health and Disease / Marcel Dekker, Inc
Asensi M / 2002 / Inhibition of cancer growth by resveratrol is related to its low bioavailability / Free Radic. Biol. Med 33:387~398
Ayala F / 2011 / Resveratrol-containing gel for the treatment of acne vulgaris : a single-blind, vehicle-controlled, pilot study / Am. J. Clin. Dermatol 12:133~141
Aziz MH / 2005 / Chemoprevention of skin cancer by grape constituent resveratrol : relevance to human disease? / FASEB J 19:1193~1195
Aggarwal BB / 2006 / Resveratrol in Health and Disease / Marcel Dekker, Inc
Asensi M / 2002 / Inhibition of cancer growth by resveratrol is related to its low bioavailability / Free Radic. Biol. Med 33:387~398
Ayala F / 2011 / Resveratrol-containing gel for the treatment of acne vulgaris : a single-blind, vehicle-controlled, pilot study / Am. J. Clin. Dermatol 12:133~141
Aziz MH / 2005 / Chemoprevention of skin cancer by grape constituent resveratrol : relevance to human disease? / FASEB J 19:1193~1195
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Inhibitory effects of resveratrol on hepatitis B virus X protein-induced hepatocellular carcinoma
Journal of Veterinary Science
2017 .12
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Resveratrol reduces the glutamate-induced cell death in hippocampal neurons
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Effect of Resveratrol on Oral Cancer Cell Invasion Induced by Lysophosphatidic Acid
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Resveratrol alleviates the symptoms of experimental autoimmune neuritis
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Resveratrol induces the apoptosis associated with activation of caspases in HTB-41 human salivary gland epidermoid carcinoma cells
Oral Biology Research
2016 .01
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Effect of the Resveratrol and Sulforaphane Compound on the Regulation of Orofacial Pain
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Resveratrol alleviates brain ischemic injury through the regulation of the Akt / GSK3 pathway
한국실험동물학회 학술발표대회 논문집
2018 .01
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Resveratrol inhibits cell growth via targeting Bmi-1 pathway in YD-10B human oral squamous cell carcinoma cells
International Journal of Oral Biology
2020 .01
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Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1 : induces apoptosis and radiosensitization in head and neck tumor cells
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2015 .10
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Resveratrol attenuates N-methyl-D-aspartate receptor-mediated activation in substantia gelatinosa neurons of trigeminal subnucleus caudalis in mice
Oral Biology Research
2023 .06
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콜라겐 유도성 관절염 마우스모델에서 레스베라트롤 식이요법의 류마티스관절염 완화효과
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2015 .01
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Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
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Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion
대한뇌졸중학회지
2024 .01
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Suppression of Syk activation by resveratrol inhibits monosodium urate crystal-induced pro-IL-1β synthesis and NLRP3 inflammasome activation in human monocytes
한국실험동물학회 학술발표대회 논문집
2018 .07
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Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells
The Korean Journal of Physiology & Pharmacology
2024 .07
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Resveratrol Inhibits Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Pathological Neovascularization
Yonsei Medical Journal
2015 .01
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Resveratrol exert beneficial effects on the defective yolk sac and chorioallantoic circulation and impaired vasculogenesis of placenta by nicotine in mice
한국실험동물학회 학술발표대회 논문집
2018 .07
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Protective Effect of Resveratrol in Neonatal Brain Damage
한국실험동물학회 학술발표대회 논문집
2016 .08
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Time - and Concentration - Dependent Effects of Resveratrol on miR 15a and miR16-1 Expression and Apoptosis in the CCRF-CEM Acute Lymphoblastic Leukemia Cell Line
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Resveratrol Promotes Self-digestion to Put Cancer to Sleep
대한암예방학회지
2024 .03
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