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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 450 - 456 (7page)
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초록· 키워드
오류제보하기
Taurine has a number of beneficial pharmacological actions in the brain such as anxiolytic and neuroprotective actions. We explored to test whether taurine could be transported to the central nervous system through the intranasal route. Following intranasal administration of taurine in mice, elevated plus maze test, activity cage test and rota rod test were carried out to verify taurine's effect on anxiety. For the characterization of potential mechanism of taurine's anti-anxiety action, mouse convulsion tests with strychnine, picrotoxin, yohimbine, and isoniazid were employed. A significant increase in the time spent in the open arms was observed when taurine was administered through the nasal route in the elevated plus maze test. In addition, vertical and horizontal activities of mice treated with taurine via intranasal route were considerably diminished. These results support the hypothesis that taurine can be transported to the brain through intranasal route, thereby inducing anti-anxiety activity. Taurine's anti-anxiety action may be mediated by the strychnine-sensitive glycine receptor as evidenced by the inhibition of strychnine-induced convulsion.
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등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Amos, S / 2004 / Behavioural effect of Pavetta cassipes extract on rodents / Pharmacol. Biochem. Behav 77:751~759
Amos, S / 2005 / Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice / J. Ethnopharmacol 97:53~57
Bigler, E. D / 1977 / Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges / Epilepsia 18:465~470
Birdsall, T. C / 1998 / Therapeutic application of taurine / Altern. Med. Rev 3:128~136
Chen, S. W / 2004 / Possible anxiolytic effects of taurine in the mouse elevated plus maze / Life Sci 75:1503~1511
Amos, S / 2005 / Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice / J. Ethnopharmacol 97:53~57
Bigler, E. D / 1977 / Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges / Epilepsia 18:465~470
Birdsall, T. C / 1998 / Therapeutic application of taurine / Altern. Med. Rev 3:128~136
Chen, S. W / 2004 / Possible anxiolytic effects of taurine in the mouse elevated plus maze / Life Sci 75:1503~1511
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