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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제6호
- 발행연도
- 2017.11
- 수록면
- 617 - 623 (7page)
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초록· 키워드
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The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 mM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 mM to 10 mM) -induced contractions was investigated. Taurine-induced relaxations were also tested in the presence of the K+ channel inhibitors tetraethylammonium (1 mM), glibenclamide (10 mM) and 4-aminopyridine (1 mM). Taurine did not affect the basal tone but inhibited the contraction induced by 5-HT and KCl. Calcium chloride? induced contractions were significantly inhibited in the presence of taurine (20, 40, 80 mM) (p<0.05). The relaxation to taurine was inhibited by tetraethylammonium (p<0.05). However, glibenclamide and 4-aminopyridine did not affect taurine -induced relaxations. Present experiments show that taurine inhibits 5-HT and KCl -induced contractions in RA, and suggest that large conductance Ca2+-activated K+ channels may be involved in taurine ?induced relaxation of RA.
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참고문헌 (28)
참고문헌 신청
Huxtable RJ / 1992 / Physiological actions of taurine / Physiol Rev 72:101~163
Oja SS / 2007 / Pharmacology of taurine / Proc West Pharmacol Soc 50:8~15
Militante JD / 2002 / Treatment of hypertension with oral taurine : experimental and clinical studies / Amino Acids 23:381~393
Kohashi N / 1983 / Decrease of urinary taurine in essential hypertension / Jpn Heart J 24:91~102
Abebe W / 2011 / Role of taurine in the vasculature : an overview of experimental and human studies / Am J Cardiovasc Dis 1:293~311
Oja SS / 2007 / Pharmacology of taurine / Proc West Pharmacol Soc 50:8~15
Militante JD / 2002 / Treatment of hypertension with oral taurine : experimental and clinical studies / Amino Acids 23:381~393
Kohashi N / 1983 / Decrease of urinary taurine in essential hypertension / Jpn Heart J 24:91~102
Abebe W / 2011 / Role of taurine in the vasculature : an overview of experimental and human studies / Am J Cardiovasc Dis 1:293~311
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