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논문 기본 정보

자료유형
학술저널
저자정보
Moon, Hansol (Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Noh, Woo Chul (Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Kim, Hyun-Ah (Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Kim, Eun-Kyu (Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Park, Ko Woon (Department of Radiology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Lee, Seung Sook (National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Choi, Joon Ho (Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Han, Kyung Woo (Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences [KIRAMS]) Byun, Byung Hyun (Department of Nuclear Medicine, Korea Cance) Lim, Ilhan Kim, Byung Il Choi, Chang Woon Lim, Sang Moo
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제50권 제3호
발행연도
2016.1
수록면
246 - 254 (9page)

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Purpose This study investigates the correlation of retention index (RI) using the dual phase FDG PET/CT scan with the breast cancer biomarkers. Methods A total of 55 patients with breast cancer underwent dual phase FDG PET/CT scans (60 and 120 min after FDG injection) before treatment. SUVmax and SUVmean of the primary breast tumors were measured, then the percent change of SUVmax and SUVmean between the two scans were calculated, and denoted as RImax and RImean, respectively. After the surgical resection of the breast tumor, the status of biomarkers (ER, PR, and HER-2) was evaluated in the postsurgical specimen. Results RImean was significantly higher in ER (-) (median, 16.2; IQR, 10.8-21.0) or HER-2 (+) (median, 16.1; IQR, 10.7-21.6) tumors than in ER (+) tumors (median, 9.9; IQR, 5.5-15.3) or HER-2 (-) tumors (median, 10.5; IQR, 5.5-16.1). However, there were no significant differences of SUVmax or RImax according to the ER or HER-2 status. There were no significant differences of any PET parameters between PR (+) and PR (-) tumors. Based off ROC curve analyses, RImean predicted the ER (+) tumors (AUC, 0.699; p = 0.006), and HER-2 (+) tumors (AUC, 0.674; p = 0.022), but not the PR (+) tumors. However, neither SUVmax nor RImax predicted ER (+), PR (+), or HER-2 (+) tumors. Conclusions Retention index of SUVmean can reflect the ER and HER-2 status of breast cancers. Higher retention index of SUVmean might associate with lower ER expression and higher HER-2 expression.

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