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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 185 - 192 (8page)
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Coculture with adipose-derived stem cells (ADSCs) can stimulate proliferation and migration of melanocytes. To enhance outcomes of skin disorders caused by melanocyte loss or death, mixed transplantation with ADSCs has been suggested. However, role of cocultured ADSCs in proliferation and migration of melanocytes remains unclear. This study determined the effect of ADSCs on production of growth factors and expression levels of intergrins in primary culture of adult human melanocytes with or without ADSCs and in nude mice grafted with such melanocytes. Higher amounts of growth factors for melanocytes, such as bFGF and SCF were produced and released from ADSCs by coculturing with melanocytes. Relative levels of integrins ${\beta}1$, ${\alpha}5$, and ${\alpha}6$ as well as adhesion to fibronectin and laminin were increased in melanocytes cocultured with ADSCs. Such increases were inhibited by neutralization of bFGF or SCF. Relative levels of bFGF, SCF and integrins were increased in nude mice skin after grafting with melanocyte+ADSC cocultures. Collectively, these results indicate that ADSCs can stimulate proliferation and migration of melanocytes by increasing expression of integrins in melanocytes through upregulation of production/release of melanocyte growth factors such as bFGF and SCF.
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참고문헌 (25)
참고문헌 신청
Ahn HH / 2014 / Cellular behavior of human adipose-derived stem cells on wettable gradient polyethylene surfaces / Int. J. Mol. Sci 15:2075~2086
Akiyama SK / 1996 / Integrins in cell adhesion and signaling / Hum. Cell 9:181~186
Bin BH / 2016 / Fibronectin-containing extracellular vesicles protect melanocytes against ultraviolet radiation-induced cytotoxicity / J. Invest. Dermatol 136:957~966
Giancotti FG / 2003 / Positional control of cell fate through joint integrin/receptor protein kinase signaling / Annu. Rev. Cell Dev. Biol 19:173~206
Halaban R / 1992 / Growth factors, receptor kinases, and protein tyrosine phosphatases in normal and malignant melanocytes / J. Immunother 12:154~161
Akiyama SK / 1996 / Integrins in cell adhesion and signaling / Hum. Cell 9:181~186
Bin BH / 2016 / Fibronectin-containing extracellular vesicles protect melanocytes against ultraviolet radiation-induced cytotoxicity / J. Invest. Dermatol 136:957~966
Giancotti FG / 2003 / Positional control of cell fate through joint integrin/receptor protein kinase signaling / Annu. Rev. Cell Dev. Biol 19:173~206
Halaban R / 1992 / Growth factors, receptor kinases, and protein tyrosine phosphatases in normal and malignant melanocytes / J. Immunother 12:154~161
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