지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 697 - 703 (7page)
이용수
초록· 키워드
오류제보하기
Background: Although Becker’s nevus (BN) is a relatively common disease, the systematic studies of clinicopathological and immunohistochemical results are poorly reported.
Objective: To investigate the clinicopathological features and immunohistochemical alterations of keratinocyte proliferation, melanocyte density, smooth muscle hyperplasia and nerve fiber distribution in BN. Methods: Clinical and pathological data were collected in 60 newly-diagnosed BN cases. Immunohistochemical stain of Ki-67, Melan-A, keratin 15, smooth muscle actin and protein gene product 9.5 was performed in 21 cases. Results: The median diagnostic and onset age was 17 and 12 years, respectively. Skin lesions usually appeared on the upper trunk and upper limbs. The pathological features included the rete ridge elongation and fusion and basal hyperpigmentation. Epidermal Ki-67, Melan-A and keratin 15 expression and dermal nerve fiber length were significantly higher in lesional and perilesional skin than in normal skin (p＜0.05∼0.01), while smooth muscle actin expression was upregulated only in skin lesion (p＜0.05). Conclusion: Although the clinical diagnosis of BN is often straightforward, histopathology is helpful to differentiate from other pigmentary disorders. The hyperproliferation of keratinocytes, melanocytes, arrector pili muscle and dermal nerve fibers could be involved in the pathogenesis of BN.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Patel P. / 2015 / Sebaceus and Becker's nevus : overview of their presentation, pathogenesis, associations, and treatment / Am J Clin Dermatol 16:197~204
Kim YJ. / 2008 / Androgen receptor overexpression in Becker nevus : histopathologic and immunohistochemical analysis / J Cutan Pathol 35:1121~1126
Rasi A. / 2014 / Hypertrichosis is not so prevalent in Becker's nevus : analysis of 47 cases / ISRN Dermatol 2014:953747
Patrizi A. / 2012 / Clinical characteristics of Becker's nevus in children : report of 118 cases from Italy / Pediatr Dermatol 29:571~574
Grande Sarpa H. / 2008 / Androgen receptor expression patterns in Becker's nevi : an immunohistochemical study / J Am Acad Dermatol 59:834~838
Kim YJ. / 2008 / Androgen receptor overexpression in Becker nevus : histopathologic and immunohistochemical analysis / J Cutan Pathol 35:1121~1126
Rasi A. / 2014 / Hypertrichosis is not so prevalent in Becker's nevus : analysis of 47 cases / ISRN Dermatol 2014:953747
Patrizi A. / 2012 / Clinical characteristics of Becker's nevus in children : report of 118 cases from Italy / Pediatr Dermatol 29:571~574
Grande Sarpa H. / 2008 / Androgen receptor expression patterns in Becker's nevi : an immunohistochemical study / J Am Acad Dermatol 59:834~838
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