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논문 기본 정보

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학술저널
저자정보
Cha, Hye Jin (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Seong, Yeon-Hee (Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Chungbuk National University) Song, Min-Ji (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Jeong, Ho-Sang (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Shin, Jisoon (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Yun, Jaesuk (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Han, Kyoungmoon (Pharmacological Researc) Kim, Young-Hoon Kang, Hoil Kim, Hyoung Soo
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제23권 제6호
발행연도
2015.1
수록면
597 - 603 (7page)

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Synthetic cannabinoids JWH-018 and JWH-250 in 'herbal incense' also called 'spice' were first introduced in many countries. Numerous synthetic cannabinoids with similar chemical structures emerged simultaneously and suddenly. Currently there are not sufficient data on their adverse effects including neurotoxicity. There are only anecdotal reports that suggest their toxicity. In the present study, we evaluated the neurotoxicity of two synthetic cannabinoids (JWH-081 and JWH-210) through observation of various behavioral changes and analysis of histopathological changes using experimental mice with various doses (0.1, 1, 5 mg/kg). In functional observation battery (FOB) test, animals treated with 5 mg/kg of JWH-081 or JWH-210 showed traction and tremor. Their locomotor activities and rotarod retention time were significantly (p<0.05) decreased. However, no significant change was observed in learning or memory function. In histopathological analysis, neural cells of the animals treated with the high dose (5 mg/kg) of JWH-081 or JWH-210 showed distorted nuclei and nucleus membranes in the core shell of nucleus accumbens, suggesting neurotoxicity. Our results suggest that JWH-081 and JWH-210 may be neurotoxic substances through changing neuronal cell damages, especially in the core shell part of nucleus accumbens. To confirm our findings, further studies are needed in the future.
#Synthetic cannabinoid #Neurotoxicity #Functional observation battery #Motor function #Histopathology

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참고문헌 (22)

참고문헌 신청
Auwarter, V. / 2009 / ‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs? / J. Mass Spectrom 44:832~837 google schola Boucard, A. / 2010 / Evaluation of neurotoxicity potential in rats: the functional observational battery. In Current Protocols in Pharmacology / John Wiley & Sons, Inc google schola Hye Jin Cha / 2014 / Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches / Biomolecules & Therapeutics 22(4):363~369 google schola Chaperon, F. / 1998 / Involvement of central cannabinoid (CB) receptors in the establishment of place conditioning in rats / Psychopharmacology 135:324~332 google schola Cheer, J. F. / 2000 / Cannabinoid receptors and reward in the rat: a conditioned place preference study / Psychopharmacology 151:25~30 google schola

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