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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 432 - 438 (7page)
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초록· 키워드
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Worldwide, caffeine is among the most commonly used stimulatory substances. Unfortunately, significant caffeine consumption is associated with several adverse effects, ranging from sleep disturbances (including insomnia) to cardiovascular problems. This study investigates whether treatment with the Evodia rutaecarpa aqueous extract (ERAE) from berries and its major molecular component, evodiamine, can reduce the adverse caffeine-induced sleep-related and excitation effects. We combined measurements from the pentobarbital-induced sleep test, the open field test, and the locomotor activity test in mice that had been dosed with caffeine. We found that ERAE and evodiamine administration reduced the degree of caffeine-induced sleep disruption during the sleep test. Additionally, we found that evodiamine significantly inhibits caffeine-induced excitation during the open field test, as well as decreasing hyperlocomotion in the locomotor activity test. Additional in vitro experiments showed that caffeine administration decreased the expression of ${\gamma}$-aminobutyric acid $(GABA)_A$ receptor subunits in the mouse hypothalamus. However, evodiamine treatment significantly reversed this expression reduction. Taken together, our results demonstrate that ERAE and its major compound, evodiamine, provide an excellent candidate for the treatment or prevention of caffeine-induced sleep disturbances and excitatory states, and that the mechanism of these beneficial effects acts, at least in part, through the $GABA_A$-ergic system.
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참고문헌 (44)
참고문헌 신청
조승목 / 2014 / Arousal Inhibitory Effect of Phlorotannins on Caffeine in Pentobarbital-Induced Mice / Fisheries and Aquatic Sciences 17(1):13~18
Dunwiddie, T. V. / 2001 / The role and regulation of adenosine in the central nervous system / Annu. Rev. Neurosci. 24:31~55
Fredholm, B. B. / 1999 / Actions of caffeine in the brain with special reference to factors that contribute to its widespread use / Pharmacol. Rev. 51:83~133
Garrett, B. E. / 1994 / $D_1$ and $D_2$ dopamine receptor antagonists block caffeine-induced stimulation of locomotor activity in rats / Pharmacol. Biochem. Behav. 47:89~94
Chagraoui, A. / 2016 / To what extent is it possible to dissociate the anxiolytic and sedative/hypnotic properties of $GABA_A$ receptors modulators? / Prog. Neuropsychopharmacol. Biol. Psychiatry 71:189~202
Dunwiddie, T. V. / 2001 / The role and regulation of adenosine in the central nervous system / Annu. Rev. Neurosci. 24:31~55
Fredholm, B. B. / 1999 / Actions of caffeine in the brain with special reference to factors that contribute to its widespread use / Pharmacol. Rev. 51:83~133
Garrett, B. E. / 1994 /
Chagraoui, A. / 2016 / To what extent is it possible to dissociate the anxiolytic and sedative/hypnotic properties of
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